“…The participants in our study and the DiRECT-UK trial each identified new and reoccurring challenges requiring resilience and tailored support. In fact, many of the experiences described by our participants appear universal: a desire for weight loss and better health as a stimulus for participation in a total diet replacement intervention [ 14 , 15 , 16 , 46 , 47 ]; the abrupt but worthwhile adjustment to a total diet replacement regimen [ 14 , 15 , 16 , 46 ]; professional support as a source of accountability [ 14 , 15 , 48 ]; drawing on rapid and early weight loss as an important motivator [ 14 , 15 , 48 ]; navigating the “disruption to adaptation” [ 14 ] (p. 7) posed by food reintroduction; the challenging realities of weight loss maintenance [ 14 , 16 , 46 , 47 , 48 , 49 ]; and the development of “behavioural autonomy” [ 49 ] (p. 956). As we identified, the timing and intensity of the challenges faced by individuals vary, and additional personal barriers frequently emerge [ 14 , 15 , 46 , 47 , 48 ].…”