2014
DOI: 10.1371/journal.pgen.1004291
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A Quality Control Mechanism Coordinates Meiotic Prophase Events to Promote Crossover Assurance

Abstract: Meiotic chromosome segregation relies on homologous chromosomes being linked by at least one crossover, the obligate crossover. Homolog pairing, synapsis and meiosis specific DNA repair mechanisms are required for crossovers but how they are coordinated to promote the obligate crossover is not well understood. PCH-2 is a highly conserved meiotic AAA+-ATPase that has been assigned a variety of functions; whether these functions reflect its conserved role has been difficult to determine. We show that PCH-2 restr… Show more

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Cited by 63 publications
(156 citation statements)
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References 68 publications
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“…Loss of PCH-2 further stabilizes pairing in syp-1 mutants (Deshong et al 2014), leading us to hypothesize that this stabilization of pairing, particularly at PCs, satisfies the synapsis checkpoint in pch-2; syp-1 and pch-2; syp-2 double mutants. We reasoned that since syp-3 and syp-4 mutants behaved differently than syp-1 and syp-2 mutants in the context of checkpoint activation, there might be similar differences with respect to PC pairing.…”
Section: Resultsmentioning
confidence: 99%
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“…Loss of PCH-2 further stabilizes pairing in syp-1 mutants (Deshong et al 2014), leading us to hypothesize that this stabilization of pairing, particularly at PCs, satisfies the synapsis checkpoint in pch-2; syp-1 and pch-2; syp-2 double mutants. We reasoned that since syp-3 and syp-4 mutants behaved differently than syp-1 and syp-2 mutants in the context of checkpoint activation, there might be similar differences with respect to PC pairing.…”
Section: Resultsmentioning
confidence: 99%
“…PCs also promote pairing and synapsis (MacQueen et al 2005) by recruiting factors, such as the zinc-fingercontaining proteins ZIM-1, ZIM-2, ZIM-3, and HIM-8 Phillips and Dernburg 2006), and the conserved polo-like kinase PLK-2 (Harper et al 2011;Labella et al 2011). We have hypothesized that the synapsis checkpoint monitors the stability of pairing at PCs as a proxy for proper synapsis (Deshong et al 2014;Bohr et al 2015). However, whether the process of synapsis is also monitored by the synapsis checkpoint is currently unknown.…”
mentioning
confidence: 99%
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“…Interestingly, several factors have been shown previously to associate transiently with the SCs during pachytene progression with a dynamics dependent on meiotic recombination. These include the predicted SUMO-ligase ZHP-3, which first associates along the lengths of SCs and then redistributes to concentrate on smaller domains defined by the crossover sites (Jantsch et al 2004;Bhalla et al 2008) and the AAA+-ATPase PCH-2, which associates with the SCs during early-mid pachytene but is lost from the chromosomes at late pachytene in a crossover-dependent manner (Deshong et al 2014). The dynamic association of these factors with the SC may represent another reflection of the transition from one synapsis phase to another that we propose in our model.…”
Section: Discussionmentioning
confidence: 99%
“…Spo11-dependent DSBs form on the chromatin loops that are tethered to the axis, and DSBs are subsequently repaired at the axis via interactions between axis proteins and Spo11-accessory factors [70,71,74,75]. Remodeling of the meiotic axes is tightly coordinated with the progression of DNA repair and crossover formation [112,113]. During mid-prophase I, following DSB formation, recombination interactions between homologues favors chromosome alignment and synaptonemal complex (SC) formation in budding yeasts, plants and mice; but not in C. elegans and female Drosophila where SC formation is independent of DSBs [14,114117].…”
Section: Chromatin Structure the Meiotic Chromosome Axes And Homologmentioning
confidence: 99%