“…Eventually, this resulted in an inclusion of 6 extra (both old and new) studies, including two new RCTs, which were not reported in the latest meta-analysis. 14,18,[29][30][31][32] Second, previous meta-analyses were hampered by inclusion of only one single pediatric study, which precluded subgroup analyses of these patients, whereas we were able to track two additional studies. Finally, the data that we obtained allowed analyses on catheter level instead of patient level, which, in addition to the sensitivity analyses, results in more precise and reliable outcomes.…”