The simulation-optimization process aims to identify the setting of input parameters leading to optimal system performance, evaluated through a simulation model of the system itself. The factors involved in the simulation model are often noisy and cannot be controlled or varied during the decision process, due to measurement errors or other implementation issues; moreover, some factors are determined by the environment, rather than by managers or decision makers. Therefore, the presumed optimal solution may turn out to be sub-optimal or even infeasible. Robust optimization tackles problems affected by uncertainty, providing solutions that are in some sense insensitive to perturbations in the model parameters.G. Dellino ( ) Istituto per le Applicazioni del Calcolo "Mauro Picone",