A quantitative in-vivo MR imaging study of brain dehydration in diabetic rats and rats treated with peptide hormones

Haraldseth, Olav; Jones, Richard A.; Skottner, A.

doi:10.1016/s0730-725x(96)00344-x

Cited by 5 publications

(6 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Differences between the groups were eliminated by insulin treatment; however, treatment with TDZD-8 (a selective inhibitor of glycogen synthase kinase-β) to replicate one important pharmacological effect of insulin resulted in almost identical benefits despite persistence of hyperglycemia. Similarly, another study demonstrated reduced ADC values in diabetic rats (45). These values were normalized with insulin treatment, but treatment with IGF-1, resulting in insulin receptor activation, was found to have similar effects on ADC despite persistence of hyperglycemia.…”

Section: Discussionmentioning

confidence: 70%

Effects of Hyperglycemia and Effects of Ketosis on Cerebral Perfusion, Cerebral Water Distribution, and Cerebral Metabolism

et al. 2012

View full text Add to dashboard Cite

Diabetic ketoacidosis (DKA) may cause brain injuries in children. The mechanisms responsible are difficult to elucidate because DKA involves multiple metabolic derangements. We aimed to determine the independent effects of hyperglycemia and ketosis on cerebral metabolism, blood flow, and water distribution. We used magnetic resonance spectroscopy to measure ratios of cerebral metabolites (ATP to inorganic phosphate [Pi], phosphocreatine [PCr] to Pi, N-acetyl aspartate [NAA] to creatine [Cr], and lactate to Cr) and diffusion-weighted imaging and perfusion-weighted imaging to assess cerebral water distribution (apparent diffusion coefficient [ADC] values) and cerebral blood flow (CBF) in three groups of juvenile rats (hyperglycemic, ketotic, and normal control). ATP-to-Pi ratio was reduced in both hyperglycemic and ketotic rats in comparison with controls. PCr-to-Pi ratio was reduced in the ketotic group, and there was a trend toward reduction in the hyperglycemic group. No significant differences were observed in NAA-to-Cr or lactate-to-Cr ratio. Cortical ADC was reduced in both groups (indicating brain cell swelling). Cortical CBF was also reduced in both groups. We conclude that both hyperglycemia and ketosis independently cause reductions in cerebral high-energy phosphates, CBF, and cortical ADC values. These effects may play a role in the pathophysiology of DKA-related brain injury.

show abstract

Section: Discussionmentioning

confidence: 70%

Effects of Hyperglycemia and Effects of Ketosis on Cerebral Perfusion, Cerebral Water Distribution, and Cerebral Metabolism

et al. 2012

View full text Add to dashboard Cite

show abstract

“…Our study did not find a significant difference in fractional anisotropy between individuals with and without diabetes, yet hyperglycaemia was associated with lower fractional anisotropy within the diabetes group at 18 months. One possible explanation is that the between-group result may be confounded by reduced diffusivity [31, 32] in conjunction with reduced myelination (i.e. the diabetes group has both reduced myelination and reduced diffusivity relative to the non-diabetes group).…”

Section: Discussionmentioning

confidence: 99%

Persistence of abnormalities in white matter in children with type 1 diabetes

et al. 2018

View full text Add to dashboard Cite

Aims/hypothesis Prior studies suggest white matter growth is reduced and white matter microstructure is altered in the brains of young children with type 1 diabetes when compared with brains of non-diabetic children, due in part to adverse effects of hyperglycaemia. This longitudinal observational study examines whether dysglycaemia alters the developmental trajectory of white matter microstructure over time in young children with type 1 diabetes. Methods One hundred and eighteen children, aged 4 to <10 years old with type 1 diabetes and 58 age-matched, non-diabetic children were studied at baseline and 18 months, at five Diabetes Research in Children Network clinical centres. We analysed longitudinal trajectories of white matter using diffusion tensor imaging. Continuous glucose monitoring profiles and HbA 1c levels were obtained every 3 months. Results Axial diffusivity was lower in children with diabetes at baseline (p = 0.022) and at 18 months (p = 0.015), indicating that differences in white matter microstructure persist over time in children with diabetes. Within the diabetes group, lower exposure to hyperglycaemia, averaged over the time since diagnosis, was associated with higher fractional anisotropy (p = 0.037). Fractional anisotropy was positively correlated with performance (p < 0.002) and full-scale IQ (p < 0.02). Conclusions/interpretation These results suggest that hyperglycaemia is associated with altered white matter development, which may contribute to the mild cognitive deficits in this population.

show abstract

“…Decreased food intake can result in decreased water intake (Oatley and Tonge, 1969), potentially resulting in dehydration. Moreover, decreased circulating insulin can promote dehydration in brain which can be reversed by insulin replacement (Haraldseth et al, 1997). Thus, it is possible that dehydration altered diffusion of pressure-ejected dopamine.…”

Section: Discussionmentioning

confidence: 99%

Feeding conditions differentially affect the neurochemical and behavioral effects of dopaminergic drugs in male rats

Sevak

Koek

Owens

et al. 2008

European Journal of Pharmacology

View full text Add to dashboard Cite

The high comorbidity of eating disorders and substance abuse suggests that nutritional status can impact vulnerability to drug abuse. These studies used rats to examine the effects of food restriction on dopamine clearance in striatum and on the behavioral effects of amphetamine (locomotion, conditioned place preference), the dopamine receptor agonist quinpirole (yawning), and the dopamine receptor antagonist raclopride (catalepsy). Amphetamine increased locomotion and produced conditioned place preference in free-feeding and food-restricted rats. Food restriction reduced dopamine clearance, which was restored by repeated treatment with amphetamine or by free feeding. Food restriction also decreased sensitivity to quinpirole-induced yawning and racloprideinduced catalepsy; normal sensitivity to both drugs was restored by free feeding. The same amphetamine treatment that normalized dopamine clearance, failed to restore normal sensitivity to quinpirole or raclopride, suggesting that in food-restricted rats the activity of dopamine transporters and dopamine receptors is differentially affected by pathways that are stimulated by amphetamine. These studies show that modest changes in nutritional status markedly alter dopamine neurotransmission and the behavioral effects of direct-acting dopamine receptor drugs (agonist and antagonist). These results underscore the potential importance of nutritional status (e.g., glucose and insulin) in modulating dopamine neurotransmission and in so doing they begin to establish a neurochemical link between the high co-morbidity of eating disorders and drug abuse.

show abstract

A quantitative in-vivo MR imaging study of brain dehydration in diabetic rats and rats treated with peptide hormones

Cited by 5 publications

References 26 publications

Effects of Hyperglycemia and Effects of Ketosis on Cerebral Perfusion, Cerebral Water Distribution, and Cerebral Metabolism

Effects of Hyperglycemia and Effects of Ketosis on Cerebral Perfusion, Cerebral Water Distribution, and Cerebral Metabolism

Persistence of abnormalities in white matter in children with type 1 diabetes

Feeding conditions differentially affect the neurochemical and behavioral effects of dopaminergic drugs in male rats

Contact Info

Product

Resources

About