A quantitative study of epidermal Langerhans cells in cutaneous leishmaniasis caused by <i>Leishmania tropica</i>

Meymandi, Simin Shamsi; Dabiri, Shahriar; Dabiri, Darya; Crawford, Richard; Kharazmi, Arsalan

doi:10.1111/j.1365-4632.2004.02359.x

Cited by 22 publications

(18 citation statements)

References 31 publications

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“…LCs are detectable in the epidermal compartment during cutaneous leishmaniasis [82,83]. Therefore, it is most likely that a re-population of epidermal LCs during infection takes place.…”

Section: Weeks After Infectionmentioning

confidence: 99%

A new view on cutaneous dendritic cell subsets in experimental leishmaniasis

Ritter

Osterloh

2006

Med Microbiol Immunol

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Because of their anatomical distribution epidermal Langerhans cells (LCs) are discussed to be crucial for antigen uptake and subsequent presentation to naïve T cells in skin-draining lymph nodes. The use of LC-specific markers like Langerin or knock-in mice expressing green fluorescent protein under the control of the Langerin promotor now facilitates the dissection of LCs from other dendritic cell (DC) subsets. Surprisingly, current data indicate that LCs are not generally involved in the induction of cellular immune responses. Moreover, the widely accepted paradigm postulating that LCs in principle act as T cell activators is contested by recent publications. Consequently, the biological role of LCs, in particular in cutaneous immune responses, needs to be revisited. The experimental model of leishmaniasis represents a suitable model to study the origin of an antigen-specific T cell response in mice. With this model the transport and presentation of skin derived Leishmania (L.) major antigens can be monitored in vivo. Furthermore, the quality of T cell-DC interactions can be determined. Considering recent progress in LC research we propose a novel concept of LCs in T cell meditated immunity against L. major parasites.

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“…LCs are detectable in the epidermal compartment during cutaneous leishmaniasis [82,83]. Therefore, it is most likely that a re-population of epidermal LCs during infection takes place.…”

Section: Weeks After Infectionmentioning

confidence: 99%

A new view on cutaneous dendritic cell subsets in experimental leishmaniasis

Ritter

Osterloh

2006

Med Microbiol Immunol

View full text Add to dashboard Cite

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“…Decreased CD1a receptor expression has also been documented with chronic Leishmania tropica and L. braziliensis guyanensis infection . Furthermore, leishmania amastigotes located intracytoplasmically within macrophages and Langerhans cells, expressed CD1a . The major inflammatory cell populations in CL were reported to consist of T cells (CD4:CD8 ratio of ~1.05), macrophages, a minute B‐cell fraction, natural killer cells and granulocytes .…”

Section: Introductionmentioning

confidence: 97%

“…Meymandi et al . identified a significant gradual decrease in epidermal CD1a‐Langerhans cell pool from 31.6 cells/mm length of epidermis in acute CL (<2 years) to 5.0 cells/mm in chronic CL (>2 years) …”

Section: Introductionmentioning

confidence: 98%

“…19,28 Furthermore, leishmania amastigotes located intracytoplasmically within macrophages and Langerhans cells, expressed CD1a. 28,29 The major inflammatory cell populations in CL were reported to consist of T cells (CD4:CD8 ratio of~1.05), macrophages, a minute B-cell fraction, natural killer cells and granulocytes. 19 Meymandi et al identified a significant gradual decrease in epidermal CD1a-Langerhans cell pool from 31.6 cells/mm length of epidermis in acute CL (<2 years) to 5.0 cells/mm in chronic CL (>2 years).…”

Section: Introductionmentioning

confidence: 99%

“…19 Meymandi et al identified a significant gradual decrease in epidermal CD1a-Langerhans cell pool from 31.6 cells/mm length of epidermis in acute CL (<2 years) to 5.0 cells/mm in chronic CL (>2 years). 28 There is no defined correlation between the distribution of CD1a expression among the different parasitic indices and Ridley patterns in CL. The aim of this study was to evaluate CD1a expression and the various inflammatory infiltrates within acute CL lesions, in association with the different parasitic indices and across the various Ridley patterns.…”

Section: Introductionmentioning

confidence: 99%

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