A quantitative weight of evidence assessment of Hill's guidelines for causal inference for cosmetic talc as a cause of mesothelioma

Ierardi, A. Michael; Urban, Ania; Marsh, Gary M.

doi:10.1016/j.taap.2021.115461

Cited by 8 publications

(1 citation statement)

References 66 publications

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“…Various industries have a high risk of asbestos exposure: petroleum refining [12]; pharmaceuticals [13]; chemicals [14]; rubber and plastics [15]; non-metallic products, basic metal manufacturing, metal processing product manufacturing, machinery, and equipment manufacturing [14,16]; electronic parts and electrical equipment manufacturing [17]; shipbuilding [18,19]. In Korea, malignant mesothelioma was reported from the construction [20], shipbuilding, and asbestos textile production industries [21].…”

Section: Introductionmentioning

confidence: 99%

Standardized Incidence Ratio and Standardized Mortality Ratio of Malignant Mesothelioma in a Worker Cohort Using Employment Insurance Database in Korea

Kim

2021

IJERPH

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Malignant mesothelioma is one of the appropriate indicators for assessing the carcinogenic effects of asbestos. This study compared the risk ratio of mesothelioma according to the industry in the worker cohort. A cohort was constructed using the Korean employment insurance system during 1995–2017, enrolling 13,285,895 men and 10,452,705 women. The standardized mortality ratio (SMR) and standardized incidence ratio (SIR) were calculated using the indirect standardization method. There were 641 malignant mesotheliomas that occurred; the SIR was significantly higher than the general population (men 1.36, 95% confidence interval(CI) 1.24–1.48, women 1.44, 95% CI: 1.23–1.7). More than half (52.8%) of malignant mesothelioma cases occurred in the manufacturing (n = 240, 38.6%, SIR: men, 1.72, 95% CI: 1.37–2.15, women, 3.31, 95% CI: 1.71–5.79) and construction industries (n = 88, 14.2%, SIR: men, 1.54 95% CI: 1.33–1.78, women, 1.62 95% CI: 1.25–2.11). The accommodation and food service (men, 2.56 95% CI: 1.28–4.58, women 1.35, 95% CI: 0.65–2.48) and real estate (men 1.34, 95% CI: 0.98–1.83, women 1.95, 95% CI: 0.78–4.02) also showed a high SIR, indicating the risk of asbestos-containing materials in old buildings. The incidence of malignant mesothelioma is likely to increase in the future, given the long latency of this disease. Moreover, long-term follow-up studies will be needed.

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Section: Introductionmentioning

confidence: 99%

Standardized Incidence Ratio and Standardized Mortality Ratio of Malignant Mesothelioma in a Worker Cohort Using Employment Insurance Database in Korea

Kim

2021

IJERPH

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Talc

Ierardi,

Burns,

Bernstein

2023

Patty's Toxicology

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Talc (Mg 3 Si 4 O 10 (OH) 2 ), a hydrated magnesium silicate, consists of magnesium (Mg), silicon and oxygen (SiO 2 , silica), and water. Inhalation of talc – in particular, cosmetic‐grade talc – has been implicated as a causal agent of mesothelioma among consumers due to the potential presence of trace levels of asbestos. Over the past several decades, the scientific community has taken several steps to evaluate this hypothesis from a human health risk assessment perspective. This chapter presents a summary of the available animal toxicology, epidemiology, and exposure data related to this topic. The focus of this chapter is primarily on cosmetic‐grade talc, as the relatively pure talc used in cosmetic applications provides the best source of data for evaluating the health effects of the mineral itself. The current weight of evidence suggests that relatively pure talc, which is used in cosmetics, as well as other consumer products, does not pose a carcinogenic health risk upon inhalation.

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A Risk Assessment of Cosmetic Talc for the Development of Mesothelioma and Ovarian Cancer

Ierardi,

Burns,

Urban

et al. 2024

Human and Ecological Risk Assessment

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A quantitative weight of evidence assessment of Hill's guidelines for causal inference for cosmetic talc as a cause of mesothelioma

Cited by 8 publications

References 66 publications

Standardized Incidence Ratio and Standardized Mortality Ratio of Malignant Mesothelioma in a Worker Cohort Using Employment Insurance Database in Korea

Standardized Incidence Ratio and Standardized Mortality Ratio of Malignant Mesothelioma in a Worker Cohort Using Employment Insurance Database in Korea

Talc

A Risk Assessment of Cosmetic Talc for the Development of Mesothelioma and Ovarian Cancer

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