We study polynomial generalizations of the Kontsevich automorphisms acting on the skew-field of formal rational expressions in two non-commuting variables. Our main result is the Laurentness and pseudo-positivity of iterations of these automorphisms. The resulting expressions are described combinatorially using a generalization (studied in [12]) of the combinatorics of compatible pairs in a maximal Dyck path developed by Lee, Li, and Zelevinsky in [8].By specializing to quasi-commuting variables we obtain pseudo-positive expressions for rank 2 quantum generalized cluster variables. In the binomial case when all internal exchange coefficients are zero, this quantum specialization provides a positive combinatorial construction of counting polynomials for Grassmannians of submodules in exceptional representations of valued quivers with two vertices.