Abstract. We define deformations of W-algebras associated to complex semisimple Lie algebras by means of quantum Drinfeld-Sokolov reduction procedure for affine quantum groups. We also introduce Wakimoto modules for arbitrary affine quantum groups and construct free field resolutions and screening operators for the deformed W-algebras. We compare our results with earlier definitions of q-W-algebras and of the deformed screening operators due to Awata, Kubo, Odake, Shiraishi [60,6,7], Feigin, E. Frenkel [22] and E. Frenkel, Reshetikhin [34]. The screening operator and the free field resolution for the deformed W-algebra associated to the simple Lie algebra sl 2 coincide with those for the deformed Virasoro algebra introduced in [60].