Abstract. Perski A, Osuchowski K, Andersson L, Sanden Å, Feleke E, Anderson G (Karolinska Institute and Hospital of the National Social Insurance Board, Nynäshamn, Sweden). Intensive rehabilitation of emotionally distressed patients after coronary by‐pass grafting. J Intern Med 1999; 246: 253–263.Objectives. To evaluate whether the status of emotionally distressed post coronary by‐pass surgery patients can be improved by a comprehensive, in‐patient rehabilitation programme.Design. Cross‐sectional.Setting. Rehabilitation hospital.Subjects. One hundred and fifty‐two post coronary by‐pass surgery patients referred to an intensive rehabilitation programme. The study group was divided into two subgroups, according to the level of emotional distress. Forty‐three (30%) out of 142 patients who completed the Nottingham Health Profile were considered to be distressed.Interventions. The comprehensive 4‐week inpatient rehabilitation programme consisted of daily physical exercise, lectures about coronary disease and risk factors, psychological support and nutrition counselling.Main outcome measures. Physical fitness, blood lipids and quality of life questionnaires.Results. The two‐way analysis of variance showed that emotionally distressed patients achieved equally good results as those obtained by nondistressed patients in performance regarding the maximal exercise stress test, maximum rate pressure product achieved, or the level of resting heart rate. Significant improvement in psychological well‐being as assessed by a seven‐point rating scale was observed in both groups. Both groups of patients were also equally successful in weight reduction and lowering of total cholesterol and triglycerides. Of all the patients who were employed at admission, twice the number of patients in the distressed group were in receipt of a permanent disability pension and half the number of patients was employed, compared to the initially nondistressed group, at 1‐year follow‐up.Conclusions. Distressed patients were very successful in improving their functional status and reducing risk factors when offered an intensive rehabilitation programme but they were much less successful in returning to work. Secondly, patients who were emotionally distressed after surgery did not differ in regard to disease status or physical capacity from nondistressed patients. They did, however, experience more angina pectoris both in daily life and when exposed to a maximal exercise stress test. Finally, the presence of emotional distress was easily detected by any measure of psychological status.