A química dos liquens

Honda, Nobuaki; Vilegas, Wagner

doi:10.1590/s0100-40421999000100018

Cited by 36 publications

(29 citation statements)

References 90 publications

(223 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This can be explained by the composition of the organic extract of C. substellata originating from the Northeast of Brazil, with approximately 98% usnic acid in its composition (Huovinen & Ahti 1986, Ahti et al 1993, Yano-Melo et al 1999). This may be primarily responsible for the antimicrobial activity demonstrated in this study and others (Burkholder et al 1944, Carrazzoni 1975, Huovinen & Ahti 1986, Ahti et al 1993, Lauterwein et al 1995, Pereira et al 1997, Honda & Vilegas 1998, Yano-Melo et al 1999, Donlan 2001, Falcão et al 2004, Ribeiro et al 2006, Moura et al 2008. Ranković et al (2012) tested the antibacterial activity of usnic acid compared to streptomycin for Bacillus mycoides (ATCC 6462), B. subtilis (ATCC 6633), S. aureus (ATCC 25923), Escherichia coli (ATCC 25922), and Klebsiella pneumoniae (ATCC 13883).…”

Section: Determination Of Antibacterial Activity Of Organic Extract Osupporting

confidence: 58%

In vitro antimicrobial activity of the organic extract of Cladonia substellata Vainio and usnic acid against Staphylococcus spp. obtained from cats and dogs

et al. 2017

View full text Add to dashboard Cite

It contains several secondary metabolites with biological activity, including usnic acid, which has exhibited a wide range of biological activities. The aim of this study was to evaluate the in vitro antimicrobial activity of the organic extract of C. substellata and purified usnic acid. Initially, Staphylococcus spp., derived from samples of skin and ears of dogs and cats with suspected pyoderma and otitis, were isolated and analyzed. In antimicrobial susceptibility testing against Staphylococcus spp., 77% (105/136) of the isolates were resistant to the antimicrobials tested. In the assessment of biofilm production, 83% (113/136) were classified as producing biofilm. In genetic characterization, 32% (44/136) were positive for blaZ, no isolate (0/136) was positive for the mecA gene, and 2% (3/136) were positive for the icaD gene. The in vitro antimicrobial activity of the organic extract of C. substellata and purified usnic acid against Staphylococcus spp. ranged from 0.25mg/mL to 0.0019mg/mL, inhibiting bacterial growth at low concentrations. The substances were more effective against biofilm-producing bacteria (0.65mg/mL-0.42mg/mL) when compared to non-biofilm producing bacteria (2.52mg/mL-2.71mg/mL). Usnic acid and the organic extract of C. substellata can be effective in the treatment of pyoderma and otitis in dogs and cats caused by Staphylococcus spp.

show abstract

Section: Determination Of Antibacterial Activity Of Organic Extract Osupporting

confidence: 58%

In vitro antimicrobial activity of the organic extract of Cladonia substellata Vainio and usnic acid against Staphylococcus spp. obtained from cats and dogs

et al. 2017

View full text Add to dashboard Cite

show abstract

“…They produce common intracellular constituents, including proteins, amino acids, polyols, carotenoids, polysaccharides, and vitamins. The secondary metabolites found in lichens are phenolics that accumulate either in the cortex or in the cell walls of medullary hyphae, and they are mainly acetyl-polymalonyl pathway derivatives (Honda, Vilegas, 1999). Furthermore, lichens are able to synthesize several metabolites, which are composed of aliphatic, cycloaliphatic, aromatic, and terpenic compounds (Huneck, 1999).…”

Section: Introductionmentioning

confidence: 99%

Anti-inflammatory and toxicity studies of atranorin extracted from Cladina kalbii Ahti in rodents

Melo

Araújo

Serafini

et al. 2011

Braz. J. Pharm. Sci.

View full text Add to dashboard Cite

Atranorin (ATR) is the main compound from the lichen Cladina kalbii Ahti, which grows in the arid regions of northeastern Brazil. This study was conducted to evaluate the anti-inflammatory and toxicological properties of ATR. To evaluate anti-inflammatory properties, paw edema was induced by injecting 0.1 mL of carrageenan into the subplantar region of the right hind paw of rats, and leukocyte migration was induced by injection of 500 µL of carrageenan into the peritoneal cavity of mice. In addition, we determined ATR cytotoxicity in L929 cells by MTT assay and acute (5 g/kg-single dose) and subchronic (50 mg/kg-30 days) toxicity tests in Wistar rats. The results showed that ATR (100 mg/kg and 200 mg/kg) exhibited significant anti-inflammatory activity (paw edema and leukocyte migration). In the acute toxicity test, the animals showed hypoactivity and lethargy during the initial period (first 6 hours) and increase in total protein, total and indirect bilirubin, and alkaline phosphatase after 14 days in ATR-treated male rats. The subchronic toxicity test revealed increases in total protein, globulin, gamma-glutamyl transferase, alkaline phosphatase, and total and direct bilirubin in ATR-treated female rats. Histological analysis revealed no changes in the architecture and morphology of the organs. These results suggest that ATR has significant anti-inflammatory activity, with no significant acute and subchronic toxicity or cytotoxicity.Uniterms: Cladina kalbii/pharmacognosy. Atranorin/anti-inflamatory activity. Atranorin/toxicity. Medicinal plants.Atranorina (ATR) é o principal composto do líquen Cladina kalbii Ahti, que cresce em terras áridas do nordeste brasileiro. Este estudo foi realizado para avaliar as propriedades antiinflamatórias e toxicológicas da ATR. Para avaliar as propriedades antiinflamatórias, o edema de pata foi induzido, administrando-se 0,1 mL de carragenina na região subplantar da pata traseira direita e a migração leucocitária foi induzida pela injeção de 500 µL de carragenina no peritônio. Além disso, determinou-se a citotoxicidade da ATR, utilizando-se a linhagem celular L929, através do teste de MTT e dos testes de toxicidade aguda (5 g/kg -dose única) e subcrônica (50 mg/kg-30 dias) em ratos Wistar. Os resultados mostraram que nas doses de (100 mg/kg e 200 mg/kg) a ATR exibiu atividade antiinflamatória significativa nos ensaios de edema de pata e migração leucocitária. Nos testes de toxicidade aguda, os animais apresentaram hipoatividade e letargia no período inicial (primeiras 6 horas) e aumento das proteínas totais, bilirrubinas total e indireta e fosfatase alcalina depois de 14 dias nos machos tratados. Para o ensaio subcrônico, houve aumento das proteínas totais, gama-glutamil-transferase, fosfatase alcalina e bilirrubina total e direta nas fêmeas tratadas com ATR. Não foram encontradas alterações na arquitetura e morfologia das lâminas histológicas observadas. Esses resultados sugerem que a ATR apresenta atividade antiinflamatória significativa, sem apresentar significativa toxicida...

show abstract

“…In spite of being described as a symbiotic association between the photosynthetic organisms and fungi, lichens are highly complex communities that produce peculiar substances with phenolic characteristic, such as the barbatic, usnic and fumaprotocetraric acids (Honda and Vilegas, 1999). Those substances come from the secondary metabolism and are known as lichen acids.…”

Section: Introductionmentioning

confidence: 99%

Cladia aggregata (lichen) from Brazilian northeast: chemical characterization and antimicrobial activity

Martins¹,

Lima²,

Silva³

et al. 2010

Braz. arch. biol. technol.

View full text Add to dashboard Cite

show abstract

A química dos liquens

Cited by 36 publications

References 90 publications

In vitro antimicrobial activity of the organic extract of Cladonia substellata Vainio and usnic acid against Staphylococcus spp. obtained from cats and dogs

In vitro antimicrobial activity of the organic extract of Cladonia substellata Vainio and usnic acid against Staphylococcus spp. obtained from cats and dogs

Anti-inflammatory and toxicity studies of atranorin extracted from Cladina kalbii Ahti in rodents

Cladia aggregata (lichen) from Brazilian northeast: chemical characterization and antimicrobial activity

Contact Info

Product

Resources

About