A Rabbit Venous Interposition Model Mimicking Revascularization Surgery using Vein Grafts to Assess Intimal Hyperplasia under Arterial Blood Pressure

Nishio, Hiroomi; Minatoya, Kenji; Masumoto, Hidetoshi

doi:10.3791/60931

Cited by 1 publication

(1 citation statement)

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“…By day 14, venous stenosis had developed, characterized by elevated stenosis area and blood flow 15 . Vein grafts are prone to stenosis because exposure to arterial blood pressure accelerates intimal hyperplasia 16 . The imbalance in vessel pressure leads to dilatation of some veins and predisposes to the formation of venous aneurysms.…”

Section: Discussionmentioning

confidence: 99%

Computational fluid dynamics simulation of hemodynamic changes in a hemodialysis patient with central venous stenosis treated with stent

Chen

Dai

Yang

et al. 2022

Seminars in Dialysis

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Background It has not been demonstrated that computational fluid dynamics (CFD) can be used to model central venous stenosis (CVS), nor that hemodynamic changes in CVS treated with stent placement can be anticipated. The purpose of this study was to demonstrate the hemodynamic performance of CVS patients treated with stent placement. Methods Patient‐specific geometric models were constructed using computed tomography images of veins from hemodialysis patients treated with stent placement. CFD simulation based on geometry was performed using ANSYS‐15 to compare pressure quantitatively, wall shear stress (WSS), and flow velocity in the brachial vein before and after stent placement. Results Following a covered stent placement, the swelling of the left upper extremity was relieved. Prior to stent implantation, the maximum and mean brachial vein wall pressures were 465.2 Pa and 224.609 Pa, respectively. It was determined that the maximum WSS value was 8.449 Pa and that the mean WSS value was 0.743 Pa. The maximum and mean flow velocities were 1.16 and 0.173 m/s, respectively. After stent placement, the maximum wall pressure, maximum WSS, and maximum flow velocity dropped by 59.4%, 71.2%, and 57.8%, respectively. The mean wall pressure, mean WSS, and mean flow rate decreased by 43.5%, 52.7%, and 17.6%, respectively. Conclusion Hemodynamics of CVS in hemodialysis patients exhibited turbulent, imbalances and disorders, which can be improved by stent placement.

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Section: Discussionmentioning

confidence: 99%