A radiation-induced adaptive response prolongs the survival of prion-infected mice

Plews, Margot; Simon, Sharon L R; Boreham, Douglas R.; Parchaliuk, Debra; Wyatt, Heather; Mantha, Rebecca R; Frost, Kathy L.; Lamoureux, Lise; Stobart, Jillian; Czub, Stefanie

doi:10.1016/j.freeradbiomed.2010.07.025

Cited by 16 publications

(15 citation statements)

References 35 publications

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“…In this light, in spite of the basic differences between our study and the above-mentioned research, both confirm the potential of adapting doses of ionizing or non-ionizing radiation for induction of adaptive response as increased resistance to a subsequent infection. The most important difference between our study and that conducted by Plews et al (2010) is the type of the adapting dose; i.e. radiofrequency as a non-ionizing radiation in our study versus gamma radiations emitted from a cobalt-60 source in Plews' (2010) study.…”

Section: Radio Frequency-induced Adaptive Responsementioning

confidence: 85%

Non-Linear Adaptive Phenomena which Decrease the Risk of Infection after Pre-Exposure to Radiofrequency Radiation

et al. 2013

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Substantial evidence indicates that adaptive response induced by low doses of ionizing radiation can result in resistance to the damage caused by a subsequently high-dose radiation or cause cross-resistance to other non-radiation stressors. Adaptive response contradicts the linear-non-threshold (LNT) dose-response model for ionizing radiation. We have previously reported that exposure of laboratory animals to radiofrequency radiation can induce a survival adaptive response. Furthermore, we have indicated that pre-exposure of mice to radiofrequency radiation emitted by a GSM mobile phone increased their resistance to a subsequent Escherichia coli infection. In this study, the survival rates in animals receiving both adapting (radiofrequency) and challenge dose (bacteria) and the animals receiving only the challenge dose (bacteria) were 56% and 20%, respectively. In this light, our findings contribute to the assumption that radiofrequency-induced adaptive response can be used as an efficient method for decreasing the risk of infection in immunosuppressed irradiated individuals. The implication of this phenomenon in human's long term stay in the space is also discussed.

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Section: Radio Frequency-induced Adaptive Responsementioning

confidence: 85%

Non-Linear Adaptive Phenomena which Decrease the Risk of Infection after Pre-Exposure to Radiofrequency Radiation

et al. 2013

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“…The first clinical sign of prion disease in this scrapie mouse model was the cessation of nesting which started approximately 16 weeks post infection. Following the cessation of nesting the mice progressed rapidly to terminal disease [17].…”

Section: Methodsmentioning

confidence: 99%

“…All urine was collected in chilled adaptors for metabolic cages and stored at −80°C until processing. Protein extraction and quantitation was performed as described above [17].…”

Section: Methodsmentioning

confidence: 99%

Urine Proteins Identified by Two-Dimensional Differential Gel Electrophoresis Facilitate the Differential Diagnoses of Scrapie

et al. 2013

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The difficulty in developing a diagnostic assay for Creutzfeldt - Jakob disease (CJD) and other transmissible spongiform encephalopathies (TSEs) stems in part from the fact that the infectious agent is an aberrantly folded form of an endogenous cellular protein. This precludes the use of the powerful gene based technologies currently applied to the direct detection of other infectious agents. To circumvent this problem our research objective has been to identify a set of proteins exhibiting characteristic differential abundance in response to TSE infection. The objective of the present study was to assess the disease specificity of differentially abundant urine proteins able to identify scrapie infected mice. Two-dimensional differential gel electrophoresis was used to analyze longitudinal collections of urine samples from both prion-infected mice and a transgenic mouse model of Alzheimer's disease. The introduction of fluorescent dyes, that allow multiple samples to be co-resolved and visualized on one two dimensional gel, have increased the accuracy of this methodology for the discovery of robust protein biomarkers for disease. The accuracy of a small panel of differentially abundant proteins to correctly classify an independent naïve sample set was determined. The results demonstrated that at the time of clinical presentation the differential abundance of urine proteins were capable of identifying the prion infected mice with 87% sensitivity and 93% specificity. The identity of the diagnostic differentially abundant proteins was investigated by mass spectrometry.

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“…Studies have reported the antiaging and life-prolonging effects of a wide variety of the so-called stressors, such as prooxidants, aldehydes, H 2 O 2 [147], CR [148–151], shear stress [152, 153], irradiation [154], radiation stress [155], UV-radiation [156], physical exercise [157], heat shock, hyperbaric conditions [158], and hypergravity. ROS production is increased by several environmental factors of stress, such as exposition to high levels of light, drought, heavy metals, salt concentrations, temperature extremes, air pollution, UV radiation, herbicides, and pathogen attacks.…”

Section: Ros and Adaptive Responsesmentioning

confidence: 99%

The Neglected Significance of “Antioxidative Stress”

Poljšak

Milisav

2012

Oxidative Medicine and Cellular Longevity

155

120

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Oxidative stress arises when there is a marked imbalance between the production and removal of reactive oxygen species (ROS) in favor of the prooxidant balance, leading to potential oxidative damage. ROSs were considered traditionally to be only a toxic byproduct of aerobic metabolism. However, recently, it has become apparent that ROS might control many different physiological processes such as induction of stress response, pathogen defense, and systemic signaling. Thus, the imbalance of the increased antioxidant potential, the so-called antioxidative stress, should be as dangerous as well. Here, we synthesize increasing evidence on “antioxidative stress-induced” beneficial versus harmful roles on health, disease, and aging processes. Oxidative stress is not necessarily an un-wanted situation, since its consequences may be beneficial for many physiological reactions in cells. On the other hand, there are potentially harmful effects of “antioxidative stress,” especially in the cases of overconsumption of synthetic antioxidants. Antioxidants can neutralize ROS and decrease oxidative stress; however, this is not always beneficial in regard to disease formation or progression (of, e.g., cancer) or for delaying aging.

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A radiation-induced adaptive response prolongs the survival of prion-infected mice

Cited by 16 publications

References 35 publications

Non-Linear Adaptive Phenomena which Decrease the Risk of Infection after Pre-Exposure to Radiofrequency Radiation

Non-Linear Adaptive Phenomena which Decrease the Risk of Infection after Pre-Exposure to Radiofrequency Radiation

Urine Proteins Identified by Two-Dimensional Differential Gel Electrophoresis Facilitate the Differential Diagnoses of Scrapie

The Neglected Significance of “Antioxidative Stress”

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