A radical approach for fluorescent turn ‘on’ detection, differentiation and bioimaging of methanol

Abstract

A simple Schiff base (RC) has been explored as a smart example of fluorescent material for the selective detection, differentiation and bioimaging of methanol. The nucleophilic attack of methanol on the cyclic control unit of RC leads to its opening and formation of a highly fluorescent moiety, RO. The RC displays a good sensitivity for MeOH with a detection limit of 0.042 wt% in water.

Highly selective and discriminative detection of small alcohols based on a dual-emission macrocyclic samarium complex

“…Compared with traditional instrumentation methods, fluorescent chemosensors exhibit great advantages in simplicity, sensitivity, selectivity, and fast and onsite applications in various domains. 18–20 Generally, to obtain an available fluorescent chemosensor, 21 researchers should elaborately organize two critical elements of sensing matrixes: the sensing site, which can interact with analytics to generate physicochemical changes and the signal indicator that transforms sensor–analyte interactions into fluorescent sensing signals, resulting in organics, 22–25 supermolecules, 26,27 polymers, 28,29 nanomaterials 30–32 and hybrids, 33–35 which served as candidates for monitoring different small alcohols. Among these reported studies, except for a few exceptions relying on the shape/size selection, 27 most alcohol chemosensors are based on the covalent bond formation strategy affected by hydroxyl groups of alcohols, 36 which often suffer from issues not only in the long response time but also poor selectivity.…”

“…Shahi 38 et al synthesized probe HNPs and studied their energy transfer modes at different viscosities. Kumar 23 et al synthesized a Schiff-base RC probe to detect methanol by making methanol attack the polarized carbonyl group (CO) at the CN ortho position. Majumder 39 et al synthesized a PMP probe with multiple polar O- and N-centres for polar determination.…”

Fluorometric Detection of Methanol by Using Triphenylamine Fluorophore Tethered Terpyridine Probe

“…Hence, there is a strong interest in developing or finding new fluorescent probes for selective sensing of methanol as well as discriminate from other alcohols. Triphenylamine (TPA) derivatives are utilized for developing aggregation induced/aggregation induced enhanced emissive materials and stimuli‐responsive smart fluorescent materials [21,22] . Donor‐acceptor TPA derivatives displayed excellent solvatofluorochromism behavior [23] .…”

“…Triphenylamine (TPA) derivatives are utilized for developing aggregation induced/aggregation induced enhanced emissive materials and stimuli-responsive smart fluorescent materials. [21,22] Donor-acceptor TPA derivatives displayed excellent solvatofluorochromism behavior. [23] Therefore, herein we have synthesized triphenylamine donor integrated terpyridine acceptor that showed strong fluorescence in solution as well as solid state.…”

Fluorometric trace methanol detection in ethanol and isopropanol in a water medium for application in alcoholic beverages and hand sanitizers

“…Despite this, few organic uorescent probes for MeOH are reported in the literature and those that are have certain limitations. 17,[28][29][30] Different materials have also been used as MeOH uorosensors such as a supramolecular ionic material by Zhang et al, 31 a bimetallic lanthanide-organic framework by Du and co-workers, 32 and nitrogen-doped oxidized carbon dots by Latha et al 33 In most of the cases MeOH is differentiated only from EtOH but not from i PrOH. The detection is based on either an increase or decrease of the relative intensity changes between MeOH and EtOH but never in the opposite direction, that is an increase for one and a decrease for the other.…”