Fiber-coupled atomic magnetometer (AM) based on a spin-exchange relaxation-free (SERF) regime has been a promising candidate for cryogenic devices for traditional magnetoencephalography (MEG) systems, as it has a flexible structure and a small lateral section for biomedical applications. The principles, key technologies, and applications of fiber-coupled AM based on the atomic spin effect are reviewed in this paper. The principle of fibercoupled AM is introduced, the characteristics of conventional and fibercoupled AMs are compared, and the development history and current situation are reviewed. In addition, according to the demands for MEG applications, the key technologies of fiber-coupled AM are summarized, and the bottleneck problems and future development directions for weak magnetic measurement are analyzed.