A Raised Level of Soluble CD8 in Bronchoalveolar Lavage Fluid in Summer-Type Hypersensitivity Pneumonitis in Japan

Hamagami, Sayo; Miyagawa, Toshi; Ochi, Tadao; Tsuyuguchi, Izuo; Kishimoto, Susumu

doi:10.1378/chest.101.4.1044

Cited by 9 publications

(4 citation statements)

References 17 publications

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“…Hypersensitivity pneumonitis (HP) is an immunologically-mediated inflammation of the lungs caused by repeated inhalation of organic dusts or other agents by a susceptible host (3,4). A diagnosis of acute presentations of HP was considered in several patients (e.g.…”

Section: Discussionmentioning

confidence: 99%

Recurrent flu-like illness with migrating pulmonary infiltrates of unknown aetiology

Bleyenbergh¹,

Nemery²,

Nolard³

et al. 2001

Respiratory Medicine

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Migrating pulmonary infiltrates present a difficult diagnostic and therapeutic challenge. We report on eight patients (mean age 51 years, range 32-78 years, with a prolonged history of migrating pulmonary infiltrates of unknown aetiology despite a very elaborate search for infectious causes, hypersensitivity pneumonitis or inhalation fever due to occupational or domestic exposure to fungi, or to other environmental causes, and for humoral or cellular immunological incompetence. These patients (one male, seven females) presented with recurrent episodes (mean 6, range 2-13) of a flu-like illness, often with cough, wheezing and pleuritic chest pain, but without systemic involvement. Previous medical histories were unremarkable. There was no relation with smoking habits, occupation, drug use or other possible exposures. Biochemical data were non-specific. There was no peripheral nor pulmonary eosinophilia; total IgE was normal, with negative RASTs and precipitins to a variety of antigens. Cultures and serological tests for bacteria, viruses, fungi, etc were non-contributory. Chest X-ray and computed tomography (CT) scan showed bilateral migratory pulmonary infiltrates, with a predilection for the middle and lower lung zones, often with a minor-to-moderate pleural effusion. Lung function tests were usually normal; at the most a slight decrease in diffusing capacity was noted in some patients. There was no or only a slight response to antimicrobials; systemic corticosteroids were not given. Further evolution was benign with patients being asymptomatic between the episodes. Despite elaborate investigations, the cause of these 'pneumonias' remains frustratingly unknown.

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Section: Discussionmentioning

confidence: 99%

Recurrent flu-like illness with migrating pulmonary infiltrates of unknown aetiology

Bleyenbergh¹,

Nemery²,

Nolard³

et al. 2001

Respiratory Medicine

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“…28,29 The classic finding is a CD4/CD8 ratio of less than 1, whereas in patients with sarcoidosis, the CD4/CD8 ratio is as high as 8 because of the CD4 1 alveolitis. 30 In patients with hypersensitivity pneumonitis, levels of T H 1 cytokines are increased, including IL-12, IL-18, and TNF-a. CD8 1 lymphocytes serve as effector cells but are not sufficiently functional.…”

Section: T H 1-related Inflammatory Conditions Hypersensitivity Pneummentioning

confidence: 99%

Pulmonary disorders, including vocal cord dysfunction

Greenberger

Grammer

2010

Journal of Allergy and Clinical Immunology

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“…1,23-25 The CD4 1 / CD8 1 ratio is less than 1 compared with 8 in sarcoidosis, which, conversely, is characterized by a CD4 1 alveolitis. 26 IFN-g participates in granuloma formation, and IL-12, IL-18, and TNF-a are just some of the cytokines involved in the pathogenesis. 27 Hypersensitivity pneumonitis can be classified into acute, subacute, and chronic stages.…”

Section: T H 1-related Inflammatory Conditions Hypersensitivity Pneummentioning

confidence: 99%

“…Some key features of hypersensitivity pneumonitis are summarized in Table I. [25][26][27][28][29][30][31][32] Avoidance of the antigen and a short course of oral corticosteroids remain the initial approach. Bird lovers might refuse to give up their birds, so that continued exposure occurs with progressive dyspnea and loss of lung function.…”

Section: T H 1-related Inflammatory Conditions Hypersensitivity Pneummentioning

confidence: 99%

7. Immunologic lung disease

Greenberger

2008

Journal of Allergy and Clinical Immunology

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A Raised Level of Soluble CD8 in Bronchoalveolar Lavage Fluid in Summer-Type Hypersensitivity Pneumonitis in Japan

Cited by 9 publications

References 17 publications

Recurrent flu-like illness with migrating pulmonary infiltrates of unknown aetiology

Recurrent flu-like illness with migrating pulmonary infiltrates of unknown aetiology

Pulmonary disorders, including vocal cord dysfunction

7. Immunologic lung disease

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