2013
DOI: 10.1073/pnas.1211309110
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A Raman-based endoscopic strategy for multiplexed molecular imaging

Abstract: Endoscopic imaging is an invaluable diagnostic tool allowing minimally invasive access to tissues deep within the body. It has played a key role in screening colon cancer and is credited with preventing deaths through the detection and removal of precancerous polyps. However, conventional white-light endoscopy offers physicians structural information without the biochemical information that would be advantageous for early detection and is essential for molecular typing. To address this unmet need, we have deve… Show more

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Cited by 207 publications
(207 citation statements)
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“…After orally introducing these biomarker-targeted NPs into the esophagus (e.g., by oral gavage or by having the subject ingest a cocktail of NPs), physicians and tumor biologists would be able to obtain a rich set of molecular information to detect cancer cells more accurately during endoscopic procedures and to study the molecular changes associated with tumor progression. Recently, a few studies have reported the multiplexed detection of large panels of nontargeted SERS NPs in live animals and human tissues [18][19][20][21][22][23][24]. Our lab and a few other groups have also developed biomarker-targeted SERS NPs and have demonstrated their specific binding abilities with cancer cells and tissues [25][26][27][28][29][30].…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…After orally introducing these biomarker-targeted NPs into the esophagus (e.g., by oral gavage or by having the subject ingest a cocktail of NPs), physicians and tumor biologists would be able to obtain a rich set of molecular information to detect cancer cells more accurately during endoscopic procedures and to study the molecular changes associated with tumor progression. Recently, a few studies have reported the multiplexed detection of large panels of nontargeted SERS NPs in live animals and human tissues [18][19][20][21][22][23][24]. Our lab and a few other groups have also developed biomarker-targeted SERS NPs and have demonstrated their specific binding abilities with cancer cells and tissues [25][26][27][28][29][30].…”
Section: Introductionmentioning
confidence: 99%
“…In light of the diagnostic potential of SERS NPs, there has been interest in the development of instruments for the spectroscopic detection and imaging of SERS NPs in tissues [19,21,23]. For example, a hand-held spectroscopic pen device has been developed for intraoperative detection of SERS signals from malignant tumors in mice [21], and a smallanimal Raman imaging system has been developed to detect multiplexed SERS signals in both superficial and deep tissue locations [20].…”
Section: Introductionmentioning
confidence: 99%
“…Silica and gold nanoparticles are the most versatile, and have been shown to, for example, exploit surface-enhanced Raman scattering (SERS) to provide super-enhancement of Raman spectra; such intrinsically multiplexed datasets enabled the endoscopic detection of flat pre-cancerous polyps 189 . Also, there are several nanoparticles for MRI that provide molecular contrast in pre-clinical development, including those with complex design such as dual 'clickable' CXCR4-targeting and matrix metalloproteinase-2/9-sensing nanoparticles 190 ; however, there is a paucity of nanoparticles in clinical use, alone or with nuclear imaging methods.…”
Section: Imaging Physiology In Patientsmentioning
confidence: 99%
“…However, the confocal laser endoscope has a small field of view (several hundreds of microns) with only contact mode. Raman-based endoscopy can detect very low concentrations (~pM) [8] with noncontact mode. However, it suffers from long image acquisition time [9].…”
Section: Introductionmentioning
confidence: 99%