A randomised comparison of regular oral oxycodone and intrathecal morphine for post-caesarean analgesia

Systematic Literature Review and Meta-Analysis of the Efficacy and Safety of Prescription Opioids, Including Abuse-Deterrent Formulations, in Non-Cancer Pain Management

“…http://onlinelibrary.wiley.com/doi/10.1111/pme.12233/suppinfo illustrates the study designs and patient characteristics of the component studies of this literature review. Of the 68 studies included in the literature review, the majority (k = 65) were clinical trials (i.e., randomized or open‐label) [12,15–73]. The remaining three studies were observational [74–76].…”

“…Forty‐four studies assessed the effects of LAOs (oxycodone [N = 13], fentanyl [N = 2], morphine [N = 19], tramadol [N = 8], methadone [N = 0], oxymorphone [N = 8]) [12,15–23,27,29,30,35,36,48–66,68–79], among which were six studies were with ADFs (morphine sulfate and naltrexone hydrochloride ER [N = 6]; oxycodone hydrochloride ER [N = 2]) [29,30,52,53,61,63,64,73]. Twenty‐two studies assessed the effects of SAOs (hydrocodone [N = 1], oxycodone [N = 13], tramadol [N = 7], codeine [N = 0]) [24–26,28,31–34,37–47,67,80,81], of which one study had an ADF as an active treatment (oxycodone hydrochloride controlled‐release [N = 1]) [28].…”

A randomized trial to compare pain control using oral analgesia with epidural analgesia after cesarean section following combined spinal-epidural anesthesia

“…McDonnell et al (2010) reported that oral oxycodone produced comparable postoperative pain relief after cesarean section to intrathecal morphine with a lower incidence of pruritus. Davis et al (2006) also pointed out that oral oxycodone-acetaminophen offered superior pain control with fewer side effects than morphine patient-controlled analgesia after cesarean section in a randomized controlled trial.…”

Post-caesarean analgesia: What is new?

“…[16] Oral oxycodone-based post-operative oral regime has been found equianalgesic to ITM after CS. [17]…”