A randomised controlled trial to compare the efficacy of preinduction with mifepristone 12 hours versus 24 hours prior for second trimister pregnancy termination

Patil, Neelamma; Gupta, Priyanka; Hittinhalli, Megha D; Mudanur, Subhaschandra R.; Tehalia, Manpreet Kaur J.; Nemagouda, Aruna S.; Kori, Shreedevi S

doi:10.18203/2320-1770.ijrcog20173498

Cited by 2 publications

(2 citation statements)

References 8 publications

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“…In the present study, 98 % of group A and 88 % of group B had a complete abortion which is statistically significant with a p-value < 0.03 and is comparable to a study done by Akkenapally P. L. [12] where 96 % had a complete abortion in mifepristone primed group and 89 % in misoprostol alone group. In a study by Patel U et al [13], the complete abortion rate was 100 % in the mifepristone-induced group and 84 % in the misoprostol-alone group.…”

Section: Discussionsupporting

confidence: 87%

“…In a study done by Nagaria et al [10] showed there is a significant reduction in the dose of misoprostol required for completeness of abortion in a mifepristone-primed group with a p-value of <0.001. In a study by Patel U et al [12], the dose required for the mifepristone pre-induced group was 122 mcg, and in the misoprostol alone group, it was 696 mcg.…”

Section: Discussionmentioning

confidence: 99%

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A comparative study of second trimester termination of pregnancy with mifepristone and misoprostol vs misoprostol alone in 50 cases

Swathi¹,

Andallu

Balasaraswathi

et al. 2022

Eureka: HS

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The aim: To study the efficacy and safety of combined mifepristone and misoprostol used in second-trimester abortion(≥ 12 and ≤ 20 weeks) in comparison with only vaginal misoprostol. Materials and methods: This study was a prospective comparative randomised clinical study in women attending hospitals in need of a second-trimester abortion, i.e., 12–20 weeks of pregnancy were taken up and divided as Group A – 50 women with mifeprisptone and misoprostol, Group B – 50 women with misoprostol alone Results were analysed according to age, parity, gestational age, average dose of misoprostol required for complete abortion, Induction abortion interval, completeness of abortion, side effects and mean days of hospital stay. Results: Demographic details are comparable and insignificant in the comparison. The average dose of misoprostol (mcg) required for the completeness of abortion in group A is 596±28.28 mcg, and in group B, it is 1148±160.66 mcg (p<0.001) which is statistically significant. In the present study, the induction abortion interval is significantly less in group A compared to group B, with p<0.001. In addition, 10 out of 50 patients in group A aborted within 7 hours, whereas none in group B. Mean duration of hospital stay in group A is 24 hours. In group B, it is 34.82 hours which is statistically significant with a p-value of <0.001. 12 patients in group A and 26 in group B had side effects like nausea, vomiting, fever, headache and diarrhoea. 8 % of group A and 20 % of group B had a fever. These patients were treated with antipyretics. 6 % in group A and 14 % in group B had nausea and vomiting and were treated with antiemetics. 4 % in group A and 8 % in group B had diarrhoea and were treated with antimotility drugs. 6 % in group A and 10 % in group B had a headache; these patients were treated with NSAIDs. Conclusions: The combination of mifepristone and misoprostol is a highly effective and safe method for second-trimester termination of pregnancy. The amount of misoprostol needed to accomplish the abortion, and the severity of the adverse effects are lower in the mifepristone-primed group than in the misoprostol-alone group. Since there are fewer difficulties, this approach can be employed in hospitals with high patient density.

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Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 99%

A comparative study of second trimester termination of pregnancy with mifepristone and misoprostol vs misoprostol alone in 50 cases

Swathi¹,

Andallu

Balasaraswathi

et al. 2022

Eureka: HS

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Critical analysis of misoprostol versus mifepristone with misoprostol in medical termination of pregnancy

Nipanal,

Doddiah,

Talawar

2023

IJOGR

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Termination of pregnancy by any method before the viable period is called abortion. Medical methods can avoid complications of surgical method of abortion which has many disadvantages like perforation of uterus, hemorrhage, sepsis and increased morbidity. The WHO has approved mifepristone and misoprostol combination for medical abortion. 1. To compare the efficacy of Misoprostol versus combination of mifepristone with Misoprostol. 2. To asses the side effects of Misoprostol and combinationion of Mifepristone and Misoprostol.It is prospective observational study consisting of two groups with each 61 subjects of MTP patients. Group A (Misoprostol alone): Receive tablet misoprostol 600 microgram start placed per vaginally followed by 400 microgram misoprostol tablet placed per vaginally every 4 hourly up to maximum five doses. In case of first trimester cases 800 microgram tablet misoprostol placed per vaginally followed by 400 microgram misoprostol tablet placed per vaginally every 4 hourly up to maximum four doses. Group B (Mifepristone and Misoprostol): Receive tablet mifepristone 200mg orally on empty stomach. After 24 hours will receive tablet misoprostol as mentioned in group A. Misoprostol alone has success rate of 78.69% whereas combination with Mifepristone success was 93.44%. The mean Induction - abortion interval in misoprostol alone group was 11.803 hours and with mifepristone combination it was B5.623 hours. Medical termination of pregnancy by sequential administration of mifepristone with misoprostol has less induction abortion interval compared to using misoprostol alone. This combination has more success rate and also has lesser side effects.

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A randomised controlled trial to compare the efficacy of preinduction with mifepristone 12 hours versus 24 hours prior for second trimister pregnancy termination

Cited by 2 publications

References 8 publications

A comparative study of second trimester termination of pregnancy with mifepristone and misoprostol vs misoprostol alone in 50 cases

A comparative study of second trimester termination of pregnancy with mifepristone and misoprostol vs misoprostol alone in 50 cases

Critical analysis of misoprostol versus mifepristone with misoprostol in medical termination of pregnancy

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