A randomised controlled trial to evaluate the efficacy of a 6-month dietary and physical activity intervention for patients receiving androgen deprivation therapy for prostate cancer

O'Neill, Raymond; Haseen, Farhana; Murray, Liam; O’Sullivan, Joe M.; Cantwell, Marie

doi:10.1007/s11764-014-0417-8

Cited by 58 publications

(113 citation statements)

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“…The pooled result for CRF was altered when omitting the study of Bourke et al 19 or O'Neill et al 23 Notably, more significantly improved results were obtained after omitting the study of Segal et al 25 On the other hand,…”

Section: Sensitivity Analysismentioning

confidence: 99%

“…Because of the nature of the interventions (self-report nature of subjective outcomes), most studies have high risk in the aspects of blinding of participants and intervention providers, except for two studies that were double-blinded. 21,23 There were two studies that referred to randomization, but no description was provided about how randomization was carried out, 11,20 while other studies used a computer-generated random digital packet. [18][19][23][24][25][26] Overall, the studies enrolled in this meta-analysis had moderate quality.…”

Section: Chinese Medical Sciences Journal March 2017mentioning

confidence: 99%

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Effects of Exercise on Cancer-related Fatigue and Quality of Life in Prostate Cancer Patients Undergoing Androgen Deprivation Therapy: A Meta-analysis of Randomized Clinical Trials

Yang¹,

Wang²

2017

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Objective To gain insight on how exercise affects the outcomes of prostate cancer patients treated with androgen deprivation therapy, specifically cancer-related fatigue (CRF) and quality of life (QoL).Methods Systematic searches for randomized clinical trials (RCTs) evaluating the effects of exercise on CRF and QoL of prostate cancer patients receiving androgen deprivation therapy were carried out to identify the eligible studies from EMBASE, PubMed and Cochrane library. Related data were extracted from eligible studies and then subjected to Reviewer Manage 5.3 for analysis. Standardized mean differences (SMD) and its 95% confidence interval (CI) were calculated.Results In all, 10 RCTs involving 841 prostate cancer patients (448 of whom exercised and 393 did not) were included in this study. With respect to CRF, there was good consistency among different studies, and it was remarkably reduced in the exercise group (SMD=−0.32, 95% CI: −0.45 to −0.18, P<0.00001, n=784). In regards to QoL, there was also good consistency among different studies, and it was also improved significantly in the exercise group (SMD=0.21, 95% CI: 0.08 to 0.34, P=0.002, n=841).Conclusion Exercise both reduced CRF and improved QoL in prostate cancer patients receiving androgen deprivation therapy.Chin Med Sci J 2017; 32(1):13-21

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Section: Sensitivity Analysismentioning

confidence: 99%

Section: Chinese Medical Sciences Journal March 2017mentioning

confidence: 99%

Effects of Exercise on Cancer-related Fatigue and Quality of Life in Prostate Cancer Patients Undergoing Androgen Deprivation Therapy: A Meta-analysis of Randomized Clinical Trials

Yang¹,

Wang²

2017

cmsj

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“…Aerobic exercise (55–80% APMHR) performed 2-3 times per week for 12-weeks, with healthy eating group based seminars every 2 weeks, has demonstrated clinically significant improvements in CRF and quality of life in sedentary men treated with ADT [19, 20]. In contrast individual nutrition advice to meet the United Kingdom Dietary guidelines [30] with 30 min per day of brisk walking for 24 weeks demonstrated no significant changes in CRF or quality of life compared to usual care [31]. Thus it appears CRF may be better managed with structured exercise prescription and concurrent healthy eating.…”

Section: Introductionmentioning

confidence: 99%

“…Literature to date has encompassed general healthy eating guidelines for the management of prostate cancer treated related side effects [19, 20, 31], however general guidelines do not take into account the specific dietary requirements needed to manage the ADT-related side effects. Therefore, the role of specific individualized nutrition therapy tailored to alleviate the side effects of ADT, particularly CRF, and improve quality of life warrants investigation.…”

Section: Introductionmentioning

confidence: 99%

Nutrition therapy with high intensity interval training to improve prostate cancer-related fatigue in men on androgen deprivation therapy: a study protocol

et al. 2017

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BackgroundCancer-related fatigue is one of the most prevalent, prolonged and distressing side effects of prostate cancer treatment with androgen deprivation therapy. Preliminary evidence suggests natural therapies such as nutrition therapy and structured exercise prescription can reduce symptoms of cancer-related fatigue. Men appear to change their habitual dietary patterns after prostate cancer diagnosis, yet prostate-specific dietary guidelines provide limited support for managing adverse side effects of treatment. The exercise literature has shown high intensity interval training can improve various aspects of health that are typically impaired with androgen deprivation therapy; however exercise at this intensity is yet to be conducted in men with prostate cancer. The purpose of this study is to examine the effects of nutrition therapy beyond the current healthy eating guidelines with high intensity interval training for managing cancer-related fatigue in men with prostate cancer treated with androgen deprivation therapy.Methods/designThis is a two-arm randomized control trial of 116 men with prostate cancer and survivors treated with androgen deprivation therapy. Participants will be randomized to either the intervention group i.e. nutrition therapy and high intensity interval training, or usual care. The intervention group will receive 20 weeks of individualized nutrition therapy from an Accredited Practising Dietitian, and high intensity interval training (from weeks 12–20 of the intervention) from an Accredited Exercise Physiologist. The usual care group will maintain their standard treatment regimen over the 20 weeks. Both groups will undertake primary and secondary outcome testing at baseline, week 8, 12, and 20; testing includes questionnaires of fatigue and quality of life, objective measures of body composition, muscular strength, cardiorespiratory fitness, biomarkers for disease progression, as well as dietary analysis. The primary outcomes for this trial are measures of fatigue and quality of life.DiscussionThis study is the first of its kind to determine the efficacy of nutrition therapy above the healthy eating guidelines and high intensity interval training for alleviating prostate-cancer related fatigue. If successful, nutrition therapy and high intensity interval training may be proposed as an effective therapy for managing cancer-related fatigue and improving quality of life in men during and after prostate cancer treatment.Trial registrationAustralian New Zealand Clinical Trials Registry ACTRN12615000512527. Trial registered on the 22/5/2015.

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“…Fatigue measurements, assessed by patient-reported questionnaires, such as the Functional Assessment of Cancer Therapy-Fatigue (FACT-F)34 or the Functional Assessment of Chronic Illness Therapy-Fatigue,35 are frequently assessed together with exercise outcomes in these studies 24,36,37. In general, the evidence is equivocal as to whether exercise helps diminish patient-reported fatigue.…”

Section: Impact Of Exercise On Patients With Prostate Cancermentioning

confidence: 99%

Integrating diet and exercise into care of prostate cancer patients on androgen deprivation therapy

Moyad

Newton²,

Tunn

et al. 2016

RRU

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Improved diagnosis and treatment regimens have resulted in greater longevity for men with prostate cancer. This has led to an increase in both androgen deprivation therapy (ADT) use and duration of exposure, and therefore to its associated adverse effects, such as sexual dysfunction, osteoporosis, reduced muscle mass, increased fat mass, and increased incidence of cardiovascular disease and type 2 diabetes. Given that the adverse effects of ADT are systemic, often debilitating, and difficult to treat, efforts continue in the development of new strategies for long-term management of prostate cancer. The PubMed database was searched to select trials, reviews, and meta-analyses in English using such search terms as “prostate cancer” and “androgen deprivation therapy”, “cardiovascular risk”, “lean body mass”, “exercise”, and “diet”. The initial searches produced 379 articles with dates 2005 or more recent. Articles published after 2004 were favored. This review utilizes the latest data to provide a status update on the effects of exercise and diet on patients with prostate cancer, focusing on ADT-associated side effects, and it discusses the evidence for such interventions. Since the evidence of large-scale trials in patients with prostate cancer is missing, and an extrapolation of supporting data to all patient subgroups cannot be provided, individualized risk assessments remain necessary before the initiation of exercise and diet programs. Exercise, diet, and nutritional supplementation interventions have the potential to provide effective, accessible, and relatively inexpensive strategies for mitigating ADT-associated toxicities without introducing additional adverse effects.

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A randomised controlled trial to evaluate the efficacy of a 6-month dietary and physical activity intervention for patients receiving androgen deprivation therapy for prostate cancer

Abstract: This study shows that a pragmatic lifestyle intervention is feasible and can have a positive impact on health behaviours and other key outcomes in men with prostate cancer receiving ADT.

Cited by 58 publications

References 45 publications

Effects of Exercise on Cancer-related Fatigue and Quality of Life in Prostate Cancer Patients Undergoing Androgen Deprivation Therapy: A Meta-analysis of Randomized Clinical Trials

Effects of Exercise on Cancer-related Fatigue and Quality of Life in Prostate Cancer Patients Undergoing Androgen Deprivation Therapy: A Meta-analysis of Randomized Clinical Trials

Nutrition therapy with high intensity interval training to improve prostate cancer-related fatigue in men on androgen deprivation therapy: a study protocol

Integrating diet and exercise into care of prostate cancer patients on androgen deprivation therapy

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