A randomised, double-blind, placebo-controlled clinical trial assessing the efficacy of bedtime buddy® for the treatment of nocturnal enuresis in children

Schloss, Janet; Ryan, Kimberley; Reid, Rebecca; Steel, Amie

doi:10.1186/s12887-019-1797-8

Cited by 10 publications

(8 citation statements)

References 35 publications

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“…A randomized double-blind placebo-controlled clinical trial assessed the efficacy of a herbal combination for the treatment of nocturnal enuresis in 80 children, but the results of this study have not yet been published (51).…”

Section: Herbal Medicinementioning

confidence: 99%

Traditional, Complementary, and Alternative Medicine in Nocturnal Enuresis in Children

Motaharifard

Mohkam

2022

JPR

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Context: The use of complementary and alternative medicine (CAM) treatments in children is increasing. Due to the ineffectiveness of some pharmacological interventions or intolerance to their side effects, different types of CAM are used in various problems such as enuresis in children. This study aimed to introduce the most common complementary and alternative medicine methods used for enuresis in the pediatric population. Evidence Acquisition: Medical literature search was performed in several databases for a variety of Traditional, Complementary and Alternative Medicine in nocturnal enuresis in Children. Databases included Google scholar, Web of Science, Scopus, Cochrane Library, PubMed and a number of Persian databases including Magiran and SID. Clinical trials, case series or case reports that had evaluated the effectiveness of these therapies in nocturnal enuresis in children were included. Data were collected in English or Persian from inception to early 2021. Results: As far as we searched, more studies have been performed on some CAM methods, such as acupuncture. In some methods, such as reflexology, the studies are limited to case reports and in others, such as aromatherapy, there was no study related to children's enuresis. Based on the results, most of CAM methods have positive effects in the treatment of nocturnal enuresis and have their unique theories about the concepts of etiology, diagnosis and treatment of disease. Conclusions: Despite the relatively high use of CAM treatments in nocturnal enuresis among children, evidence of their effectiveness is not enough. More clinical trials are required to evaluate safety and efficacy of these methods.

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Section: Herbal Medicinementioning

confidence: 99%

Traditional, Complementary, and Alternative Medicine in Nocturnal Enuresis in Children

Motaharifard

Mohkam

2022

JPR

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“…The most common used herbal medicine for pediatric asthmatic patients were linden (21.6%) and ginger (21.2%) [34]. Herbal medicine has traditionally been used in the treatment of symptoms for nocturnal enuresis or urinary incontinence [35][36][37].…”

Section: Areas Of Herbal Medicinal Product Usementioning

confidence: 99%

Safety of Herbal Medicines in Children

Polat¹,

Gürol²

2021

Alternative Medicine - Update

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Herbal medicine is used by individuals of all ages, including children. Herbal medicine includes herbs, herbal materials and preparations, and finished herbal products. Herbal medicine or herbal products’ use for all ages have increased in recent years. Based on the data of the World Health Organization, almost 80% of the population in developing countries trust herbal medicines to meet their health needs. Herbal medicines use unconsciously as though these products are harmless. The use of herbal products in children is a concern because little information is available concerning the benefits and risks of these products in the pediatric population. This creates a serious problem in the treatment of children, and reveals a serious and under-recognized hazard in clinical care. The safety of most herbal medicinal products is absent since lack of suitable quality controls and not available of appropriate patient information. Owing to the possibility of serious health complications arising from the use of herbal products, it is mandatory to understand their use in the general population in order for appropriate measures to be put into place.

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“…Lupeol has been found to function through the toll like receptor 4/myeloid differentiation primary response 88/NF-κB p65, IL-1 receptor-associated kinase and p38 MAPK pathways (16). It has been previously tested in clinical studies for the treatment of cancer (such as bone, liver, lung, colon, rectum and bladder), actinic keratosis and nocturnal enuresis (17)(18)(19). In a study conducted with actinic keratosis patients, the birch-bark-containing Lupeol managed to clear 75% of the lesions (18).…”

Section: Introductionmentioning

confidence: 99%

Protective effects of lupeol in rats with renal ischemia‑reperfusion injury

Kapisiz,

Kaya,

Eryilmaz

et al. 2024

Exp Ther Med

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Acute kidney injury (AKI) caused by ischemia and, exogenous or endogenous nephrotoxic agents poses a serious health issue. AKI is seen in 1% of all hospital admissions, 2-5% of hospitalizations and 67% of intensive care unit (ICU) patients. The in-hospital mortality rates for AKI is 40-50, and >50% for ICU patients. Ischemia-reperfusion (I/R) injury in the kidney can activate inflammatory responses and oxidative stress, resulting in AKI. The common endpoint in acute tubular necrosis is a cellular insult secondary to ischemia or direct toxins, which results in effacement of brush border, cell death and decreased function of tubular cells. The aim of the present study was to assess if the reported antioxidant and anti-inflammatory agent lupeol can exert any effects against renal I/R damage. In total, 24 Wistar Albino rats were randomly assigned into four groups of 6, namely Sham, lupeol, ischemia and therapy groups. In the lupeol group, intraperitoneal administration of 100 mg/kg lupeol was given 1 h before laparotomy, whilst only laparotomy was conducted in the sham group. The renal arteries of both kidneys were clamped for 45 min, 1 h after either intraperitoneal saline injection (in the ischemia group) or 100 mg/kg lupeol application (in the therapy group). The blood samples and renal tissues of all rats were collected after 24 h. In blood samples, blood urea nitrogen (BUN) was measured by the urease enzymatic method, and creatinine was measured by the kinetic Jaffe method. Using ELISA method, TNF-α and IL-6 levels were measured in the blood samples, whereas malondialdehyde (MDA), glutathione (GSH), caspase-3 levels were measured in kidney tissues. In addition, kidney histopathological analysis was performed by evaluating the degree of degeneration, tubular dilatation, interstitial lymphocyte infiltration, protein cylinders, necrosis and loss of brush borders. It was determined that renal damage occurred due to higher BUN, creatinine, MDA, TNF-α and caspase-3 values observed in the kidney tissues and blood samples of rats in ischemia group compared with the Sham group. Compared with those in the ischemia group, rats in the therapy group exhibited increased levels of GSH and reduced levels of BUN, TNF-α, MDA. Furthermore, the ischemia group also had reduced histopathological damage scores. Although differences in creatinine, IL-6 and caspase-3 levels were not statistically significant, they were markedly reduced in the treatment group. Taken together, these findings suggest that lupeol can prevent kidney damage as mainly evidenced by the reduced histopathological damage scores, decreased levels of oxidative stress and reduced levels of inflammatory markers. These properties may allow lupeol to be used in the treatment of AKI.

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A randomised, double-blind, placebo-controlled clinical trial assessing the efficacy of bedtime buddy® for the treatment of nocturnal enuresis in children

Cited by 10 publications

References 35 publications

Traditional, Complementary, and Alternative Medicine in Nocturnal Enuresis in Children

Traditional, Complementary, and Alternative Medicine in Nocturnal Enuresis in Children

Safety of Herbal Medicines in Children

Protective effects of lupeol in rats with renal ischemia‑reperfusion injury

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