A randomised multicentre trial of CHART versus conventional radiotherapy in head and neck cancer

Correlation of Computerized Tomography density patterns of lymph nodes with treatment results and outcome in head and neck cancer patients treated by 2 different chemoradiotherapy schedules

“…[8,9] Regimens using accelerated radiation therapy have been somewhat disappointing in that although loco regional control rates may be improved, there has been unacceptable acute and late toxicity. [10][11][12] Hyperfractionated radiation regimens have shown improved loco regional control compared to conventional radiation therapy, [13] which may be further enhanced with concurrent chemotherapy, [14] but this doubles radiation machine workloads. It is now accepted that chemotherapy is more effective when given concurrently rather than sequentially with radiation therapy.…”

Raynaud’s phenomenon after radical radiotherapy for tumours of the head and neck

“…1 The high dose target volume including the tongue base, part of the oral tongue, and the upper deep cervical nodes received a total dose of 56.75 Gy in 36 fractions over 12 days. The dose to elective nodal areas was 37.5 Gy in 25 fractions of 1.5 Gy.…”

Translational Research&A New Entity?

“…A period of ve years was required until adequate numbers were included and this was achieved in April 1995. An initial report was made the following year (10) but the de nitive reports concerning the two trials were not published until 1997 and 1998 (11,12). The implementation into clinical practice in non-small cell lung cancer, is presently still being effected and the approach is still far from being universally accepted even in the United Kingdom where it was developed (13).…”

“…If the radiation dose had been 4% greater and if a gamma value of 2 applies, then the difference might have been 12%, which would certainly have been statistically signi cant (12). One can conclude that a randomized controlled trial should test the exact regimen employed in the pilot study.…”