A randomised study of prophylactic G‐CSF following MRC UKALL XI intensification regimen in childhood ALL and T‐NHL

Little, Margaret; Morland, Bruce; Chisholm, Julia; Hole, Alison; Shankar, Ananth; Devine, Tom; Easlea, D.; Meyer, L; Pinkerton, CR

doi:10.1002/mpo.1279

Cited by 25 publications

(1 citation statement)

References 38 publications

(39 reference statements)

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“…For this meta-analysis, 16 articles were included (2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17). Studies were included if 1) the population consisted of children (age defined by the individual study) or data were extractable for those less than age 18 years in studies that included adults and children; 2) there was randomization between CSFs and placebo or no therapy; 3) CSFs were given after initiation of chemotherapy, prophylactically, before neutropenia or febrile neutropenia developed; and 4) identical chemotherapy immediately preceded CSF and placebo administration or no therapy.…”

Section: Review Methodsmentioning

confidence: 99%

A Bayesian Meta-analysis of Prophylactic Granulocyte Colony-Stimulating Factor and Granulocyte-Macrophage Colony-Stimulating Factor in Children with Cancer

Sung

Beyene²,

Hayden³

et al. 2006

American Journal of Epidemiology

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The purpose of this analysis was to examine the efficacy of prophylactic hematopoietic colony-stimulating factors (CSFs) in pediatric cancer and to describe how a Bayesian meta-analysis can be conducted and then modified to incorporate information not readily included in a frequentist meta-analysis. Three Bayesian models were developed. The simplest model used the same data as a published frequentist meta-analysis. The second model included data that could not easily be incorporated into the frequentist meta-analysis, including data from different courses of chemotherapy and continuous outcomes that did not report variance estimates. The third model examined the effect of CSF type (granulocyte CSF vs. granulocyte-macrophage CSF). Compared with the frequentist model, the Bayesian model with the most data suggested a greater benefit of CSFs, with a 3.2-day reduction in duration of parenteral antibiotics (95% credible interval: -7.1, 0.7) in the expanded Bayesian model compared with a 0.8-day (95% confidence interval: -2.3, 0.7) reduction in the frequentist model. Bayesian meta-analysis also suggested that, compared with granulocyte-macrophage CSF, granulocyte CSF was associated with a 4.8-day decrease in the duration of parenteral antibiotics. Bayesian meta-analysis can readily include information not easily incorporated in a frequentist meta-analysis. Some treatment effect estimates were larger by a clinically important amount when additional data contributed to the pooled estimate.

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Section: Review Methodsmentioning

confidence: 99%

A Bayesian Meta-analysis of Prophylactic Granulocyte Colony-Stimulating Factor and Granulocyte-Macrophage Colony-Stimulating Factor in Children with Cancer

Sung

Beyene²,

Hayden³

et al. 2006

American Journal of Epidemiology

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Colony-stimulating factors for prevention of myelosuppressive therapy-induced febrile neutropenia in children with acute lymphoblastic leukaemia

Sasse

Brandalise

et al. 2005

Cochrane Database of Systematic Reviews

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Children with ALL treated with CSF benefit from shorter hospitalisation and fewer infections. However, there was no evidence for a shortened duration of neutropenia nor fewer treatment delays, and no useful information about survival. The role of CSF regarding febrile neutropenia episodes is still uncertain. Although current data shows statistical benefit for CSF use, substantial heterogeneity between included trials does not allow this conclusion.

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Prophylactic antibiotics or G-CSF for the prevention of infections and improvement of survival in cancer patients undergoing chemotherapy

Herbst

Naumann

Kruse

et al. 2009

Cochrane Database of Systematic Reviews

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A randomised study of prophylactic G‐CSF following MRC UKALL XI intensification regimen in childhood ALL and T‐NHL

Abstract: This study shows that the prophylactic administration of G-CSF following intensification chemotherapy for childhood ALL and T-NHL produces a significant reduction in the rate of readmission to hospital for the management of febrile neutropenia.

Cited by 25 publications

References 38 publications

A Bayesian Meta-analysis of Prophylactic Granulocyte Colony-Stimulating Factor and Granulocyte-Macrophage Colony-Stimulating Factor in Children with Cancer

A Bayesian Meta-analysis of Prophylactic Granulocyte Colony-Stimulating Factor and Granulocyte-Macrophage Colony-Stimulating Factor in Children with Cancer

Colony-stimulating factors for prevention of myelosuppressive therapy-induced febrile neutropenia in children with acute lymphoblastic leukaemia

Prophylactic antibiotics or G-CSF for the prevention of infections and improvement of survival in cancer patients undergoing chemotherapy

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