A randomised trial of nutrient supplements to minimise psychological stress after a natural disaster

Kaplan, Bonnie; Rucklidge, Julia J.; Romijn, Amy R.; Dolph, Michael

doi:10.1016/j.psychres.2015.05.080

Cited by 38 publications

(44 citation statements)

References 37 publications

(41 reference statements)

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“…A meta-analysis demonstrated the importance of dose, frequency and achieving measurable increases in 25(OH)D concentrations in being able to detect favourable depression outcomes [ 61 ]. Our results support those of Kaplan et al who demonstrated that vitamin B complex and multivitamin/mineral formulas have resulted in greater reductions in stress and anxiety compared with vitamin D 3 supplementation alone [ 29 ]. A systematic review of the evidence demonstrates a significant number of trials that overall provide sufficient support for the use of B vitamins in the treatment of stress and anxiety in the general population, the benefit of which may be augmented with a broad array of minerals [ 13 ].…”

Section: Discussionsupporting

confidence: 91%

“…A multivitamin/mineral (MVM), in which many ingredients were given at levels higher than recommended dietary allowance (RDA) but generally lower than the upper level (UL), has been shown to improve depressive symptoms in bipolar individuals [ 25 , 26 , 27 , 28 , 29 ]. A MVM was also found to significantly reduce stress and anxiety following a series of earthquakes and a flood [ 22 , 29 , 30 , 31 ]. Despite enrolling participants who were not clinically depressed, two clinical trials have found that micronutrient supplementation improved symptoms of depression [ 32 , 33 ].…”

Section: Introductionmentioning

confidence: 99%

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Database Analysis of Depression and Anxiety in a Community Sample—Response to a Micronutrient Intervention

2018

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Background: Depression and anxiety are common mental health concerns worldwide. Broad-spectrum multi-vitamin/mineral approaches have been found to alleviate a number of psychiatric symptoms. We investigated the effects of a nutrient intervention program, which includes optimizing vitamin D levels, on depression and anxiety outcomes from community-based program. Methods: We evaluated self-reported health measures of depression and anxiety collected as part of a community-based program focused on optimizing overall health through nutritional supplementation, education and lifestyle advice. Results: Data were collected from 16,020 participants, with measures including European Quality of Life Five Dimensions (EQ-5D) and Targeted Symptoms List (TSL) providing self-reported depression and anxiety. More than 56% of participants were identified as having elevated levels of depression and anxiety at baseline as reported on the EQ-5D. After one year in the program, 49.2% (n = 7878) of participants who reported any level of depression or anxiety at baseline reported improvement at follow-up. Of those who reported severe/extreme depression at baseline (n = 829), 97.2% reported improvement after one year. Regression analyses revealed a significant association of improvement in depression and anxiety with higher vitamin D status (>100 nmol/L) and more strenuous physical activity. Conclusion: Overall, people from the general population who suffer from mood and anxiety problems may benefit from improved nutritional status achieved with nutritional supplements.

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Database Analysis of Depression and Anxiety in a Community Sample—Response to a Micronutrient Intervention

2018

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“…Along with attempting to replicate the effects observed from taurine, future research should also investigate the potential benefits of other neuroprotective nutrients in FEP. Cross-sectional research indicates that folate and vitamin D are worthy candidates for adjunctive treatment trials, given that people with FEP have particularly low circulating levels for both of these in comparison to age-and gendermatched controls (Firth, Carney, et al, 2017), even when controlling for other factors such as dietary nutrition intake (Kale et al, 2010 (Kaplan, Rucklidge, Romijn, & Dolph, 2015;Oulhaj, Jernerén, Refsum, Smith, & de Jager, 2016;Rucklidge, Johnstone, & Kaplan, 2013). There is increasing interest in using multi-nutrients to target mechanistic pathways implicated in neuropsychiatric conditions (Dean et al, 2015;Oulhaj et al, 2016;Sarris, Stough, et al, 2015;Sarris, Logan, et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

Adjunctive nutrients in first‐episode psychosis: A systematic review of efficacy, tolerability and neurobiological mechanisms

Firth

Rosenbaum

Ward

et al. 2018

Early Intervention Psych

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AimThe effects of nutrient‐based treatments, including adjunctive vitamin or antioxidant supplementation, have been explored extensively in long‐term schizophrenia. However, no systematic evaluation of trials in “first‐episode psychosis” (FEP) has been conducted, despite the potential benefits of using these treatments during the early stages of illness. Therefore, we aimed to review all studies examining efficacy, tolerability and the biological mechanisms of action, of nutrient supplementation in FEP.MethodsA systematic review of electronic databases was conducted from inception to July 2017. All information on feasibility, clinical outcomes and mechanistic findings from nutrient supplementation clinical trials was extracted and systematically synthesized.ResultsEleven studies with a total of 451 patients with FEP (from 8 independent randomized controlled trials) were eligible for inclusion. Six studies examined omega‐3 fatty acids, with inconsistent effects on psychiatric symptoms. However, mechanistic studies found significant improvements in hippocampal neuronal health and brain glutathione. Antioxidants “n‐acetyl cysteine” (n = 1) and vitamin C (n = 2) also improved oxidative status in FEP, which was associated with reduced psychiatric symptoms. No benefits were found for vitamin E (n = 1). Finally, one study trialling the amino acid taurine, showed significant improvements in positive symptoms and psychosocial functioning.ConclusionThere is preliminary evidence that taurine improves outcomes in FEP, whereas effects of omega‐3 and antioxidant vitamins/amino‐acids are inconsistent; perhaps mainly benefitting patients with high levels of oxidative stress. Future studies should evaluate multifaceted dietary and supplementation interventions in FEP; targeting‐specific nutritional deficits and the range of aberrant biological processes implicated in the disorder.

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“…Stough et al [ 27 ] reported reductions in personal strain as measured by the Occupational Stress Inventory, in addition to reduced depression-dejection and confusion ratings on the Profile of Mood States after 90 days of MVM supplementation in healthy adults. Recent evidence suggests that MVM supplementation may also reduce stress and anxiety in the period following a natural disaster [ 28 , 29 , 30 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of Four-Week Supplementation with a Multi-Vitamin/Mineral Preparation on Mood and Blood Biomarkers in Young Adults: A Randomised, Double-Blind, Placebo-Controlled Trial

et al. 2015

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This study explored the effects of four-week multi-vitamin and mineral (MVM) supplementation on mood and neurocognitive function in healthy, young adults. Fifty-eight healthy adults, 18–40 years of age (M = 25.82 years, SD = 4.87) participated in this randomised, double-blind, placebo-controlled trial, in which mood and blood biomarkers were assessed at baseline and after four weeks of supplementation. Compared to placebo, MVM supplementation was associated with significantly lowered homocysteine and increased blood B-vitamin levels (p < 0.01). MVM treatment was also associated with significantly improved mood, as measured by reduced scores on the “depression-dejection” subscale of the Profile of Mood States (p = 0.018). These findings suggest that the four weeks of MVM supplementation may have beneficial effects on mood, underpinned by elevated B-vitamins and lowered homocysteine in healthy young adults.

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A randomised trial of nutrient supplements to minimise psychological stress after a natural disaster

Cited by 38 publications

References 37 publications

Database Analysis of Depression and Anxiety in a Community Sample—Response to a Micronutrient Intervention

Database Analysis of Depression and Anxiety in a Community Sample—Response to a Micronutrient Intervention

Adjunctive nutrients in first‐episode psychosis: A systematic review of efficacy, tolerability and neurobiological mechanisms

Effects of Four-Week Supplementation with a Multi-Vitamin/Mineral Preparation on Mood and Blood Biomarkers in Young Adults: A Randomised, Double-Blind, Placebo-Controlled Trial

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