A randomized clinical trial evaluating negative pressure therapy to decrease vascular groin incision complications

Kwon, Jeontaik; Staley, Cara; McCullough, Megan; Goss, Selena; Arosemena, Mariano; Abai, Babak; Salvatore, Dawn; Reiter, David; DiMuzio, Paul

doi:10.1016/j.jvs.2018.05.224

Cited by 79 publications

(141 citation statements)

References 41 publications

Supporting

Mentioning

136

Contrasting

Order By: Relevance

“…All the included studies reported a reduced incidence of SSIs in the NPWT group compared with the standard dressing group. The results were significant in three studies. Meta‐analysis of the seven studies, including all incisions from all arterial procedures, showed a reduction of SSIs, with an OR of 0·35 (95 per cent c.i.…”

Section: Resultsmentioning

confidence: 92%

“…). Of these, seven studies (from 13 records) were considered to have met the inclusion criteria: Kwon et al ,. Gombert et al ,.…”

Section: Resultsmentioning

confidence: 99%

“…Two studies had a high risk of detection bias because the evaluations for SSIs were not blinded. Three studies had an unclear risk of detection bias because any blinding of the assessor was not stated in their reports.…”

Section: Resultsmentioning

confidence: 99%

“…Two studies had a high risk of reporting bias. Gombert and colleagues received industry sponsorship from KCI (an Acelity Company, San Antonio, Texas, USA), the manufacturer of the interventional dressing (Prevena™ Incision Management System) and did not address all the secondary outcomes listed in the study protocol.…”

Section: Resultsmentioning

confidence: 99%

“…The secondary outcomes, seroma formation, wound dehiscence and scar formation, were reported in only three studies. Two participants in the study of Kwon and colleagues developed a seroma, both in the standard dressing group (2 of 60, 3 per cent). No patient had wound dehiscence.…”

Section: Resultsmentioning

confidence: 99%

See 4 more Smart Citations

Meta-analysis of negative pressure wound therapy of closed groin incisions in arterial surgery

Svensson‐Björk

Zarrouk

Asciutto

et al. 2019

British Journal of Surgery

View full text Add to dashboard Cite

Background: Surgical-site infection (SSI) after groin incisions for arterial surgery is common and may lead to amputation or death. Incisional negative pressure wound therapy (NPWT) dressings have been suggested to reduce SSIs. The aim of this systematic review with meta-analysis was to assess the effects of incisional NPWT on the incidence of SSI in closed groin incisions after arterial surgery.Methods: A study protocol for this systematic review of RCTs was published in Prospero (CRD42018090298) a priori, with predefined search, inclusion and exclusion criteria. The records generated by the systematic research were screened for relevance by title and abstract and in full text by two of the authors independently. The selected articles were rated for bias according to the Cochrane risk-of-bias tool.Results: Among 1567 records generated by the search, seven RCTs were identified, including 1049 incisions. Meta-analysis showed a reduction in SSI with incisional NPWT (odds ratio (OR) 0⋅35, 95 per cent c.i. 0⋅24 to 0⋅50; P < 0⋅001). The heterogeneity between the included studies was low (I 2 = 0 per cent). The quality of evidence was graded as moderate. Two studies had multiple domains in the Cochrane risk-of-bias tool rated as high risk of bias. A subgroup meta-analysis of three studies of lower limb revascularization procedures only (363 incisions) demonstrated a similar reduction in SSI (OR 0⋅37, 0⋅22 to 0⋅63; P < 0⋅001; I 2 = 0 per cent).Conclusion: Incisional NPWT after groin incisions for arterial surgery reduced the incidence of SSI compared with standard wound dressings. The risk of bias highlighted the need for a high-quality RCT with cost-effectiveness analysis.

show abstract

Section: Resultsmentioning

confidence: 92%

“…). Of these, seven studies (from 13 records) were considered to have met the inclusion criteria: Kwon et al ,. Gombert et al ,.…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 3 more Smart Citations

Meta-analysis of negative pressure wound therapy of closed groin incisions in arterial surgery

Svensson‐Björk

Zarrouk

Asciutto

et al. 2019

British Journal of Surgery

View full text Add to dashboard Cite

show abstract

Negative pressure wound therapy for surgical wounds healing by primary closure

Webster

Liu

Norman

et al. 2019

Cochrane Database of Systematic Reviews

132

View full text Add to dashboard Cite

Negative pressure wound therapy for surgical wounds healing by primary closure

Norman

Goh

Dumville

et al. 2020

Cochrane Database of Systematic Reviews

109

View full text Add to dashboard Cite

BackgroundIndications for the use of negative pressure wound therapy (NPWT) are broad and include prophylaxis for surgical site infections (SSIs). While existing evidence for the effectiveness of NPWT remains uncertain, new trials necessitated an updated review of the evidence for the effects of NPWT on postoperative wounds healing by primary closure. ObjectivesTo assess the effects of negative pressure wound therapy for preventing surgical site infection in wounds healing through primary closure. Search methodsWe searched the Cochrane Wounds Specialised Register, CENTRAL, Ovid MEDLINE (including In-Process & Other Non-Indexed Citations), Ovid Embase, and EBSCO CINAHL Plus in February 2018. We also searched clinical trials registries for ongoing and unpublished studies, and checked reference lists of relevant included studies as well as reviews, meta-analyses, and health technology reports to identify additional studies. There were no restrictions on language, publication date, or setting. Selection criteriaWe included trials if they allocated participants to treatment randomly and compared NPWT with any other type of wound dressing, or compared one type of NPWT with another type of NPWT. Data collection and analysisFour review authors independently assessed trials using predetermined inclusion criteria. We carried out data extraction, 'Risk of bias' assessment using the Cochrane 'Risk of bias' tool, and quality assessment according to GRADE methodology.

show abstract

A randomized clinical trial evaluating negative pressure therapy to decrease vascular groin incision complications

Cited by 79 publications

References 41 publications

Meta-analysis of negative pressure wound therapy of closed groin incisions in arterial surgery

Meta-analysis of negative pressure wound therapy of closed groin incisions in arterial surgery

Negative pressure wound therapy for surgical wounds healing by primary closure

Negative pressure wound therapy for surgical wounds healing by primary closure

Contact Info

Product

Resources

About