A randomized clinical trial of radiation therapy versus thermoradiotherapy in stage IIIB cervical carcinoma

Hirabayashi, Yoko; Nagata, Kenji; Harima, K; Ostapenko, Valentina V.; Tanaka, Yoshimasa; Sawada, Satoshi

doi:10.1080/02656730903092018

Cited by 119 publications

(107 citation statements)

References 19 publications

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“…HT in combination with other treatments has been considered a promising approach in cancer therapy (3)(4)(5)(6)(7). Thus, the current data will help enable the rational design of more effective strategies for future HT therapy in OSCC cells.…”

Section: Discussionmentioning

confidence: 99%

“…Local hyperthermia (HT) for various malignant tumors including OSCC has been recognized as an effective and attractive tool with the advantages of relatively few side effects and slight damage to normal tissue. Combinations of HT with chemotherapy, radiotherapy or both have been clinically used for patients with cancer in various organs, and their antitumor effects have been verified by many clinical trials (3)(4)(5)(6)(7).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Gene networks related to the cell death elicited by hyperthermia in human oral squamous cell carcinoma HSC-3 cells

Tabuchi

Wada

Furusawa³

et al. 2011

Int J Mol Med

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Abstract. Local hyperthermia (HT) for various types of malignant tumors has shown promising antitumor effects. To confirm the detailed molecular mechanism underlying cell death induced by HT, gene expression patterns and gene networks in human oral squamous cell carcinoma (OSCC) cells were examined using a combination of DNA microarray and bioinformatics tools. OSCC HSC-3 cells were treated with HT at 44˚C for 90 min or mild hyperthermia (MHT) at 42˚C for 90 min, followed by culturing at 37˚C for 0-24 h. Treatment of cells with HT prevented cell proliferation (62%) and induced cell death (17%), whereas these alterations were not observed in cells treated with MHT. Microarray analysis revealed substantial differences with respect to gene expression patterns and biological function for the two different hyperthermic treatments. Moreover, we identified the temperature-specific gene networks D and H that were obtained from significantly up-regulated genes in the HT and MHT conditions, respectively, using Ingenuity pathway analysis tools. Gene network D, which contains 14 genes such as ATF3, DUSP1 and JUN, was associated with relevant biological functions including cell death and cellular movement. Gene network H, which contains 13 genes such as BAG3, DNAJB1 and HSPA1B, was associated with cellular function and maintenance and cellular assembly and organization. These findings provide a basis for understanding the detailed molecular mechanisms of cell death elicited by HT in human OSCC cells. IntroductionIn the treatment of oral squamous cell carcinoma (OSCC), treatment outcomes have improved in the past two decades due to progress in reconstructive techniques, stereotactic radiotherapy, new anticancer drugs such as taxanes, and combinations of these therapeutic modalities (1). Nonetheless, it is well known that patients with advanced tumors or tumor recurrence have a poor prognosis with a median survival period less than one year (2). Local hyperthermia (HT) for various malignant tumors including OSCC has been recognized as an effective and attractive tool with the advantages of relatively few side effects and slight damage to normal tissue. Combinations of HT with chemotherapy, radiotherapy or both have been clinically used for patients with cancer in various organs, and their antitumor effects have been verified by many clinical trials (3-7).In general, HT elicits a wide spectrum of stress responses such as induction of heat shock proteins (HSPs), protein aggregation, an imbalance of protein homeostasis, DNA and RNA damage, reactive oxygen species production, cell growth arrest and cell death in mammalian cells (8,9). In particular, HSPs, which are induced by heat, behave as molecular chaperones and exert strong cytoprotective effects that prevent cell death. The treatment of cells with HT induces numerous signal transduction pathways which contribute variously to cell death and survival (10-12). Although many biological processes are affected by HT, the overall responses to HT in mammalian cells remain unknown.Re...

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Gene networks related to the cell death elicited by hyperthermia in human oral squamous cell carcinoma HSC-3 cells

Tabuchi

Wada

Furusawa³

et al. 2011

Int J Mol Med

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“…Further study of uterine cervix carcinoma showed the benefit of survival [48], but the distant metastases were more than three times higher when hyperthermia was combined with radiotherapy compared to the earlier data [49]. The cervix study also showed better four-year survival when radiotherapy was used alone than when combined with hyperthermia [50].…”

Section: How Local Is the Local Treatment?mentioning

confidence: 63%

Heating Preciosity—Trends in Modern Oncological Hyperthermia

Szász¹,

Szász²,

Minnaar³

et al. 2017

OJBIPHY

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The use of hyperthermia as a treatment in oncology is a common topic for debate. Some researchers expect a breakthrough in oncological treatments with hyperthermia, whereas others have disregarded the method. Serious questions concerning hyperthermia have arisen. Should homogeneous (isothermal) or heterogeneous (selective) heating being used? When we use selective heating (heterogeneity), should the entire tumour be targeted or should the malignant cells be individually selected? Does the mechanism involve thermal cell death or thermally-assisted cell death? Is the goal necrosis or apoptosis? Is hyperthermia safe as a monotherapy or does it have to be combined with conventional treatments? When the selection is local, how do we act on disseminated cells that represent a high risk of life threatening metastases? When local heating is the focus, how should it be carried out with measured and controlled? Our objective is to show how precise, selective heat transfer is necessary to remove malignant cells and, consequently, how hyperthermia as part of the immune-oncology can change the game in this promising field of oncological therapies.

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“…Some early clinical studies indicated problems with survival time, but in fact, this was ignored. It was shown that radiotherapy and complementary hyperthermia have positive outcomes regarding local control compared to solely applied radiotherapy [138]; however, the measured survival was lower in the Complete Remission (CR) group of patients in the hyperthermia + radiotherapy arm. On the other hand, for patients having not CR, the survival rate was higher in the combined arm than in the arm where radiotherapy was solely applied.…”

Section: Introduction and Interpretation Of A Relative "Old Method" Imentioning

confidence: 99%

What is on the Horizon for Hyperthermic Cancer Therapy?

GyP¹,

Dy²,

Hegyi³

2017

J Tradi Med Clin Natur

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A randomized clinical trial of radiation therapy versus thermoradiotherapy in stage IIIB cervical carcinoma

Cited by 119 publications

References 19 publications

Gene networks related to the cell death elicited by hyperthermia in human oral squamous cell carcinoma HSC-3 cells

Gene networks related to the cell death elicited by hyperthermia in human oral squamous cell carcinoma HSC-3 cells

Heating Preciosity—Trends in Modern Oncological Hyperthermia

What is on the Horizon for Hyperthermic Cancer Therapy?

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