A randomized clinical trial of hyaluronic acid gel pulpotomy in primary molars with 1 year follow-up

Ildeş, Gökçe Çiçek; Sezgin, Batın Ilgıt; Vieira, Alexandre R.; Menteş, Ali

doi:10.1080/00016357.2021.1998612

Cited by 5 publications

(31 citation statements)

References 24 publications

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“…Sonmez et al [37] reported swelling ndings in 2 teeth in the FC group in a two-year study, and in the study by Petel et al [41], sinus tract formation was observed in 2 teeth in the FC group. In our RCT with a 1-year follow-up [29] and the present retrospective study, no teeth showed spontaneous, nocturnal pain and/or swelling.…”

Section: Discussionmentioning

confidence: 41%

“…Consistent with our ndings, Sushynski et al [36], Noorollahian [38], and Petel et al [41], with a minimum follow-up period of 2 years, similarly reported a signi cant reduction in the number of initially treated teeth by the nal follow-up period. The mean age of the children included in our study was slightly higher than that reported in the aforementioned studies, and due to the treatment of 67 rst primary molars out of the 130 primary molars treated (51.5%) [29], we believe this ratio increased in alignment with the physiological exfoliation times of these teeth.…”

Section: Discussionmentioning

confidence: 55%

“…This retrospective study is the extension of the 1-year survey of our RCT study that had compared the effectiveness of a HA pulpotomy over FC and FS pulpotomies [29] and included clinical and radiographic evaluations with a follow-up period of over 24 months for 44 children (27 girls, 17 boys) who applied to the Department of Paediatric Dentistry at Marmara University between May 2019 and September 2019 and underwent pulpotomy treatments using HA, FC, and FS materials. This study was performed in line with the principles of the Declaration of Helsinki.…”

Section: Methodsmentioning

confidence: 99%

“…In our previous randomized clinical trial (RCT), encompassing a 1-year follow-up, we found that HA, FC, and FS agents used in pulpotomy treatments of human primary molar teeth yielded comparable success rates both clinically and radiographically [29]. Building upon these outcomes, the aim of this retrospective study was to determine the long-term clinical and radiographic success of our previous RCT [29] and to compare the success of HA, a promising agent for pulpotomy treatment, with the widely used FC and FS agents.…”

Section: Introductionmentioning

confidence: 98%

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Hyaluronic acid as a pulpotomy material in primary molars: an up to 30 months retrospective study

Sezgin,

Koyuncu

et al. 2024

Preprint

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Objectives The aim of this retrospective study was to determine the long-term clinical and radiographic success of our previous randomized clinical trial (RCT) and to compare the success of hyaluronic acid (HA), with the widely used formocresol (FC) and ferric sulphate (FS) agents. Materials and methods This retrospective study is the extension of the 1-year survey of our RCT that had compared the effectiveness of a HA pulpotomy over FC and FS pulpotomies and included clinical and radiographic evaluations with a follow-up period of over 24 months for 44 children who applied to our clinic between May 2019 and September 2019. Long-term clinical and radiographic data were obtained from the periodic files of our department, wherein each tooth's file was examined to identify any clinical and radiographic findings. Descriptive statistics and Pearson chi-square tests were used to evaluate the data. Statistical significance was considered as p<0.05. Results The clinical and radiographic success rates of the HA, FC, and FS groups were not statistically different at >24 months (p=0.163 and p=0.977, respectively). None of the teeth in the HA group showed any clinical findings at >24 months. Conclusions HA pulpotomies exhibited comparable success rates to FC and FS materials spanning over 24 months examinations. Further long-term follow-up human studies are needed to better understand the effect of HA on the dental pulp of human primary molars. Clinical relevance Because of convenient accessibility and applicability of HA, it may be recommended as a promising alternative medicament for pulpotomy treatments of primary molars.

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Section: Discussionmentioning

confidence: 41%

Section: Discussionmentioning

confidence: 55%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

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Hyaluronic acid as a pulpotomy material in primary molars: an up to 30 months retrospective study

Sezgin,

Koyuncu

et al. 2024

Preprint

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“…Pulpotomy continued to be the most widely used endodontic treatment modality in primary dentition [45]. Several pulpotomy medicaments and techniques have also been proposed and used in primary molars, such as FC, FS, MTA, CH, glutaraldehyde (GA), NaOCl, biodentine, lasers and electrosurgery [77]; none are considered ideal [5,20].…”

Section: Discussionmentioning

confidence: 99%

Comparative efficacy of medicaments or techniques for pulpotomy of primary molars: a network meta-analysis

2022

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Objectives We performed this network meta-analysis to determine the comparative efficacy of formocresol (FC), ferric sulfate (FS), sodium hypochlorite (NaOCl), calcium hydroxide (CH), mineral trioxide aggregate (MTA), biodentine, and laser for pulpotomy of molar teeth. Materials and methods An updated search was conducted in PubMed, Embase, and the Cochrane Library to identify relevant randomized controlled trials (RCTs) published before October 30, 2022, after screening previous meta-analyses. The Cochrane risk of bias assessment tool was used to appraise the methodological quality of included studies. Clinical and radiographic success rates were assessed as outcomes. Random network meta-analysis was performed by using STATA software (version 14.0) with “network” command. Results A total of 43 RCTs were included. Network meta-analysis indicated that CH was inferior to other medicaments and techniques in all outcomes, and MTA and biodentine was better than FC, FS, and NaOCl in terms of clinical and radiographic success rates. Results of ranking probabilities suggested that MTA ranked first in all outcomes except for clinical success at both 6 months. Conclusions Our results suggested that MTA was associated with significant improvement in both clinical and radiographic success than other pulpotomy medicaments and techniques, with the highest probability of being the optimal option. Clinical relevance The current network meta-analysis determined the comparative efficacy and safety of 7 common pulpotomy medicaments in molar pulpotomy, including FC, FS, NaOCl, CH, MTA, biodentine, and laser, and the pooled results revealed comparable efficacy in clinical and radiographic success rates at 6 and 12 months between FC, FS, and NaOCl in primary molars pulpotomies. However, MTA, biodentine and laser may have more advantages than other pulpotomy medicaments for clinical and radiographic success. Therefore, in clinical practice, practitioners should select MTA, biodentine, or laser as pulpotomy medicaments in molar pulpotomy.

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Histological evaluation of different concentrations of hyaluronic-acid-added zinc oxide eugenol on rat molar pulp

Bektas,

Hazar Yoruc,

Cinel

et al. 2024

Odontology

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Hyaluronic acid (HA), known for diverse properties, was investigated for its potential in dental pulp therapy. This study investigated the potential of HA in dental pulp therapy by examining the physical properties and effects of zinc oxide eugenol (ZOE) pulpotomy materials containing varying HA concentrations on rat molar teeth. In vitro tests assessed compressive strength and hardness of ZOE materials blended with HA (0.5%, 1%, 3%) and HA gels (0.54%, 0.8%). 120 samples, encompassing the control group, underwent compressive strength testing, while 60 samples were designated for hardness assessment. In vivo experiments on rat molars studied histological effects of HA-containing ZOE on dental pulp over 1 week and 1 month. Gels with HA concentrations of 0.5%, 1%, and 0.54% were used in pulpotomy on 22 rats. Each rat underwent the procedure on four teeth, with one tooth serving as a control, totaling 88 teeth subjected to the intervention. In the analyses, SPSS 22.0 was used and the significance level was set at P = 0.05. Findings showed that HA at 0.5% maintained compressive strength, but higher concentrations decreased mechanical properties significantly (P = 0.001). Histological assessments indicated better outcomes with lower HA concentrations in terms of odontoblast layer continuity (P = 0.005 at 1 month) and pulp vitality (P = 0.001 at 1 week and P = 0.018 at 1 month). The study suggests HA holds promise for pulpotomy and regenerative endodontic treatments, but further research is needed to understand long-term clinical implications.

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A randomized clinical trial of hyaluronic acid gel pulpotomy in primary molars with 1 year follow-up

Cited by 5 publications

References 24 publications

Hyaluronic acid as a pulpotomy material in primary molars: an up to 30 months retrospective study

Hyaluronic acid as a pulpotomy material in primary molars: an up to 30 months retrospective study

Comparative efficacy of medicaments or techniques for pulpotomy of primary molars: a network meta-analysis

Histological evaluation of different concentrations of hyaluronic-acid-added zinc oxide eugenol on rat molar pulp

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