A Randomized Clinical Trial of Antimicrobial Duration for Cystic Fibrosis Pulmonary Exacerbation Treatment

Cystic fibrosis year in review 2021

“…69 The optimal length for PEx was the subject of the STOP-2 trial. 70 If a participant had at least 8% improvement in FEV1pp and 11-point decrease in CRISS by Days 7-10 of exacerbation, then 10 days of IV antibiotics was not inferior to 14 days. For those participants without an improvement at 7-10 days, 21 days of IV antibiotics was not superior to 14 days.…”

“…The optimal length for PEx was the subject of the STOP‐2 trial 70 . If a participant had at least 8% improvement in FEV1pp and 11‐point decrease in CRISS by Days 7–10 of exacerbation, then 10 days of IV antibiotics was not inferior to 14 days.…”

A year in review: Real world evidence, functional monitoring and emerging therapeutics in 2021

“…The diagnosis and management of pulmonary exacerbations (PExs) remain a major topic of interest. STOP2 reported that shorter duration of antibiotic therapy for PExs is not inferior to longer courses [82] . Almost 1000 adult PwCF were enrolled and randomized based on their clinical response after 7–10 days of intravenous antibiotic treatment.…”

“…Conflicting data on the effectiveness of CRP as a biomarker have been published. In the STOP2 study, CRP was not a good predictor for a PEx diagnosis, whereas others have proposed a step wise algorithm using CRP thresholds and fold-change from stable may be used to diagnose a PEx when there are conflicting data between changes in lung function and symptoms [ 82 , 85 ]. Whilst this review does not permit us to examine all potential biomarkers in detail, the Biomarker Special Interest Working Group published a review highlighting neutrophil elastase, IL-8, TNF-α and IL-1β as valid biomarkers of lung inflammation.…”

Cystic fibrosis year in review 2021

“…Optimal length for PEx was the subject of the STOP-2 trial 69 . If a participant had at least 8% improvement in FEV1pp and 11-point decrease in CRISS by day 7-10 of exacerbation, then 10 days of IV antibiotics was not inferior to 14 days.…”