A randomized clinical trial of oxidized regenerated cellulose adhesion barrier (Interceed, TC7) alone or in combination with heparint

Reid, Robert L.; Hahn, Philip M.; Spence, J.E.H.; Tulandi, Togas; Yuzpe, A. Albert; Wiseman, David M.

doi:10.1016/s0015-0282(97)81850-x

Cited by 57 publications

(40 citation statements)

References 17 publications

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“…In previous randomized controlled trials, Interceed ® has already been shown to have the efficacy and safety for preventing postoperative abdominal adhesion; 46,47 this potency was also confirmed in this study. In comparison to pure PLGA membranes, E(8)-PLGA membranes showed much better preventive effects of adhesion.…”

supporting

confidence: 83%

PLGA nanofiber membranes loaded with epigallocatechin-3-O-gallate are beneficial to prevention of postsurgical adhesions

Shin¹,

Yang²,

Lee³

et al. 2014

IJN

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This study concentrates on the development of biodegradable nanofiber membranes with controlled drug release to ensure reduced tissue adhesion and accelerated healing. Nanofibers of poly(lactic- co -glycolic acid) (PLGA) loaded with epigallocatechin-3- O -gallate (EGCG), the most bioactive polyphenolic compound in green tea, were electrospun. The physicochemical and biomechanical properties of EGCG-releasing PLGA (E-PLGA) nanofiber membranes were characterized by atomic force microscopy, EGCG release and degradation profiles, and tensile testing. In vitro antioxidant activity and hemocompatibility were evaluated by measuring scavenged reactive oxygen species levels and activated partial thromboplastin time, respectively. In vivo antiadhesion efficacy was examined on the rat peritonea with a surgical incision. The average fiber diameter of E-PLGA membranes was approximately 300–500 nm, which was almost similar to that of pure PLGA equivalents. E-PLGA membranes showed sustained EGCG release mediated by controlled diffusion and PLGA degradation over 28 days. EGCG did not adversely affect the tensile strength of PLGA membranes, whereas it significantly decreased the elastic modulus and increased the strain at break. E-PLGA membranes were significantly effective in both scavenging reactive oxygen species and extending activated partial thromboplastin time. Macroscopic observation after 1 week of surgical treatment revealed that the antiadhesion efficacy of E-PLGA nanofiber membranes was significantly superior to those of untreated controls and pure PLGA equivalents, which was comparable to that of a commercial tissue-adhesion barrier. In conclusion, the E-PLGA hybrid nanofiber can be exploited to craft strategies for the prevention of postsurgical adhesions.

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supporting

confidence: 83%

PLGA nanofiber membranes loaded with epigallocatechin-3-O-gallate are beneficial to prevention of postsurgical adhesions

Shin¹,

Yang²,

Lee³

et al. 2014

IJN

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“…[14] Oxidized regenerated cellulose (Interceed ® ) has a beneficial effect on adhesions by forming a physical separation of adjacent peritoneal surfaces. [15] Polyethylene glycol (SprayGel ® ) consists of two synthetic liquid precursors that, when mixed, rapidly cross-link to form a solid, flexible, absorbable hydrogel. [16] hylan G-F 20 (Synvisc ® ) is a high-molecular-weight, reticulated hyaluronic acid.…”

Section: Resultsmentioning

confidence: 99%

“…[21,22] Reid et al [15] conducted a prospective clinical study in which they evaluated 40 female patients with a history of adhesiolysis because of ovarian adhesions or cystectomy due to ovarian cyst. They covered both of the ovaries with TC-7, but sprayed heparin solution over one of them.…”

Section: Discussionmentioning

confidence: 99%

Prevention Of adhesion To prosthetic mesh: Comparison Of Oxidized Generated Cellulose, Polyethylenglycol And Hyalen GF 20 (An Experimental Study)

Altınlı¹

2011

Ulus Travma Acil Cerrahi Derg

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“…Bu yayınlardaki bulgular bizim çalışmamızdaki ile benzerlik göstermektedir. DMAH'lerin total adezyon skorunu azaltmadığına dair raporlar da bulunmaktadır [18,19]. Bizim çalışmamızda enoksaparin adezyon şiddetinden ziyade adezyon yaygınlığını azaltarak total adezyon skorunu kontrol grubuna göre düşük olmasını sağlamıştır.…”

Section: Discussionunclassified

Sıçan uterin horn modelinde enoksaparin ve rapamisinin adezyon oluşumuna etkilerinin karşılaştırılması

Tayyar¹,

Özgün²,

Akgün³

2013

CMJ

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ÖzetAmaç. Birçok çalışmada düşük molekül ağırlıklı heparinlerin (DMAH) postoperatif adezyon gelişimini önlemede etkili olduğu, bazı çalışmalarda da rapamisinin immünosüpresif bir ajan olarak postoperatif adezyon gelişimini azaltabileceği saptanmıştır. Bu deneysel çalışmada bir DMAH olan enoksaparin ile rapamisinin tek tek veya birlikte adezyon oluşumu üzerine etkileri sıçan uterin horn modelinde incelendi. Yöntem. Çalışmada ağırlıkları 200-250 gr arasında olan 40 adet Wistar-Albino dişi sıçan kullanıldı. Sıçanların karın duvarına anestezi altında steril koşullarda 3 cm'lik orta hat kesisi yapıldı. Her iki uterin hornda antimezenterik yüzeye 8-10 adet unipolar koterizasyon uygulandı ve antimezenterik yüzeyler 4/0 polidioksanon ile karın ön duvar peritonuna dikildi. Sıçanlar kontrol, enoksaparin, rapamisin ve enoksaparin ve rapamisin gruplarına (n= 10) ayrıldı. Kontrol grubunda adezyon önleyici tedavi uygulanmadan karın katları usulüne uygun olarak kapatıldı. Enoksaparin grubunda 14 gün süreyle enoksaparin 50 U/kg intraperitoneal olarak uygulandı. Rapamisin grubunda 14 gün süreyle 0,8 mg/kg oral yoldan gavaj tüpüyle rapamisin uygulandı. Enoksaparin ve rapamisin grubunda 14 gün süreyle enoksaparin 50 U/kg intraperitoneal olarak verildi, ayrıca aynı süreyle 0,8 mg/kg oral yoldan gavaj tüpüyle rapamisin ilave olarak uygulandı. Sıçanların tümü 14 gün sonra letal doz pentobarbital ile öldürülerek orta hat kesisi ile laparotomi yapılarak adezyon gelişimi gözle ve histopatolojik olarak değerlendirildi. Bulgular. Makroskopik ve mikroskopik olarak incelendiğinde çalışma gruplarının adezyon şiddetleri benzer bulundu (p>0,05). İlaç uygulanan grupların adezyon yaygınlığı ve total adezyon skorları kontrol grubununkine göre daha düşük bulundu (p<0,05). İlaç uygulanan grupların adezyon yaygınlığı ve total adezyon skorları arasında anlamlı fark bulunmadı (p>0,05). Sonuç. Enoksaparin ve rapamisin benzer düzeylerde total adezyonu önlemekte, bunu yaparken adezyon şiddetinden daha çok adezyon yaygınlığını azaltarak etkili olmaktadır. Birlikte kullanımlarında ise adezyon oluşumu üzerine etkileri sinerjistik değildir.Anahtar sözcükler: Düşük molekül ağırlıklı heparin, enoksaparin, rapamisin, peritoneal adezyon AbstractAim. Several studies have demonstrated that low molecular weight heparins (LMWHs) decreased postoperative adhesion formation. Also, a few studies have noted that immunosuppressive agent rapamycin decreased postoperative adhesion formation. In this experimental study, we aimed to investigate the effect of enoxaparin and rapamycin alone and in combination on the adhesion formation in a rat uterine horn model. Methods. Our study included 40 Wistar-Albino rats weighing between 200-250 g. Control and three study groups were formed including 10 rats. In sterile condition, we performed 3-cm midline incision of abdominal wall under general anesthesia. On the antimesenteric surface of both uterine horns, 8-10 unipolar electrocauterization were applied. Later these antimesenteric surfaces were sutured to abdominal sidewalls with 4....

show abstract

A randomized clinical trial of oxidized regenerated cellulose adhesion barrier (Interceed, TC7) alone or in combination with heparint

Cited by 57 publications

References 17 publications

PLGA nanofiber membranes loaded with epigallocatechin-3-O-gallate are beneficial to prevention of postsurgical adhesions

PLGA nanofiber membranes loaded with epigallocatechin-3-O-gallate are beneficial to prevention of postsurgical adhesions

Prevention Of adhesion To prosthetic mesh: Comparison Of Oxidized Generated Cellulose, Polyethylenglycol And Hyalen GF 20 (An Experimental Study)

Sıçan uterin horn modelinde enoksaparin ve rapamisinin adezyon oluşumuna etkilerinin karşılaştırılması

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