A Randomized Clinical Trial on the Effect of Low-Level Laser Therapy on Chronic Diabetic Foot Wound Healing: A Preliminary Report

Kaviani, Ahmad; Djavid, Gholamreza Esmaeeli; Ataie‐Fashtami, Leila; Fateh, Mohsen; Ghodsi, Maryam; Salami, Maliheh; Zand, Nasrin; Kashef, Nasim; Larijani, Bagher

doi:10.1089/pho.2009.2680

Cited by 117 publications

(123 citation statements)

References 28 publications

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“…A double-blind clinical trial [42] also confirmed accelerated reduction of ulcer size and larger number of patients with complete healing in the group who received laser therapy. Heliumneon and infra-red laser therapy of diabetes-related skin lesions improved blood flow parameters compared with patients who had only received conventional treatment [43].…”

Section: Laser Therapymentioning

confidence: 75%

Selected physical medicine interventions in the treatment of diabetic foot syndrome

et al. 2016

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The diabetic foot syndrome (DFS) is among chronic complications of diabetes mellitus; it can affect individuals with both type 1 and type 2 diabetes. Diabetic patients have up to a 25% lifetime risk of developing DFS, which is both a medical and social problem. Several studies have indicated that, apart from pharmacotherapy and modern active wound dressings, physical medicine also has a role in prevention and management of diabetic foot ulcers. The paper presents physical medicine interventions most recognized in the conservative management of DFS.

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Section: Laser Therapymentioning

confidence: 75%

Selected physical medicine interventions in the treatment of diabetic foot syndrome

et al. 2016

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“…Wound size was significantly reduced at week 4 in the low-level laser therapy compared with the placebo group, and at week 20 eight patients in the treatment group and only three in the placebo group achieved complete wound healing. The mean duration until complete wound healing was not statistically significant: week 11 in the treatment group compared to week 14 in the control group [54] . These limited data suggest there may be a role for low-level laser therapy in accelerating healing of diabetic foot ulcers wound.…”

Section: Electrotherapy Methodsmentioning

confidence: 68%

“…Presumably this was related to the increased skin blood circulation and contributed to improved healing [53] . In another randomized controlled trial of patients with a diabetic foot ulcer, 13 received lowlevel laser therapy and 10 patients were in a placebo group [54] . Wound size was significantly reduced at week 4 in the low-level laser therapy compared with the placebo group, and at week 20 eight patients in the treatment group and only three in the placebo group achieved complete wound healing.…”

Section: Electrotherapy Methodsmentioning

confidence: 99%

Does physical therapy and rehabilitation improve outcomes for diabetic foot ulcers?

Turan

Ertuğrul

Lipsky

et al. 2015

WJEM

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One of the most common and serious complications of diabetes mellitus is ulceration of the foot. Among persons with diabetes, 12%-25% will present to a healthcare institution for a foot disorder during their lifespan. Despite currently available medical and surgical treatments, these are still the most common diabetes-related cause of hospitalization and of lower extremity amputations. Thus, many adjunctive and complementary treatments have been developed in an attempt to improve outcomes. We herein review the available literature on the effectiveness of several treatments, including superficial and deep heaters, electro-therapy procedures, prophylactic methods, exercise and shoe modifications, on diabetic foot wounds. Overall, although physical therapy modalities seem to be useful in the treatment of diabetic foot wounds, further randomized clinical studies are required.

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“…In addition to increased MMP-9, other studies have also found increased levels of MMP-2 and -8 [4][5][6]. PBM has been shown to stimulate cells and wound healing, and has aided in the healing of chronic diabetic ulcers [8][9][10][11][12][13]. Aparecida Da Silva and co-workers irradiated diabetic induced male Wistar rats (660 nm, 4 J/cm2) and evaluated MMP-2 and -9, and Type I and III collagen 24 h post-irradiation [25].…”

Section: Resultsmentioning

confidence: 99%

“…This leads to an increase in adenosine triphosphate (ATP) which in turn activates a cascade of intracellular signals and messengers, leading to various down-stream effects such as increased proliferation, cellular migration and viability, collagen production, as well as gene transcription [8]. There are several research papers which demonstrate the beneficial effect of PBM in the treatment of diabetic ulcers [9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Influence of 660 and 830 nm Laser Irradiation on Genetic Profile of Extracellular Matrix Proteins in Diabetic Wounded Human Skin Fibroblast Cells

Houreld

2016

Proceedings of the 2016 International Conference on Biomedical and Biological Engineering

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Abstract. The extracellular matrix (ECM) provides tissue structural integrity and its synthesis plays a crucial role in wound healing. Impaired wound healing ensues following the destruction of the ECM, or the inhibition of its synthesis. An imbalance in ECM synthesis and degradation is seen in patients with diabetes. This has led to the development of novel therapies that aim to decrease ECM destruction and increase its synthesis. Photobiomodulation (PBM) has been shown to speed up the healing of these slow-to-heal wounds, and numerous studies are being conducted to determine the underlying molecular cause. This study aimed to ascertain the effect of laser irradiation at a wavelength of 660 or 830 nm at a dose of 5 J/cm 2 on the genetic expression profile of genes involved in ECM proteins. cDNA was reverse transcribed from total isolated RNA and used in real-time qualitative polymerase chain reaction (qPCR). Genes concerned with the basement membrane, collagen and ECM structural constituents, and ECM protesases and inhibitors were evaluated. Results showed that a similar genetic profile (although not identical) was seen post irradiation. PBM was able to reduce the expression of ECM proteases and increase mRNA levels of ECM proteins. This study fortifies the notion that PBM stimulates cellular activity and can influence ECM matrix synthesis and degradation during wound healing. This study has also shown that PBM is able to stimulate cells at a genetic level.

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A Randomized Clinical Trial on the Effect of Low-Level Laser Therapy on Chronic Diabetic Foot Wound Healing: A Preliminary Report

Abstract: The study provides evidence that LLLT can accelerate the healing process of chronic diabetic foot ulcers, and it can be presumed that LLLT may shorten the time period needed to achieve complete healing.

Cited by 117 publications

References 28 publications

Selected physical medicine interventions in the treatment of diabetic foot syndrome

Selected physical medicine interventions in the treatment of diabetic foot syndrome

Does physical therapy and rehabilitation improve outcomes for diabetic foot ulcers?

Influence of 660 and 830 nm Laser Irradiation on Genetic Profile of Extracellular Matrix Proteins in Diabetic Wounded Human Skin Fibroblast Cells

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