A randomized, comparative study of lamivudine plus stavudine, with indinavir or nelfinavir, in treatment-experienced HIV-infected patients

Abstract

Adherence to a HAART regimen with stavudine plus lamivudine plus nelfinavir was superior to a regimen with stavudine plus lamivudine plus indinavir. Side-effects provoked more discontinuation of treatment in the indinavir group than in the nelfinavir group.

Women and Vulnerability to HAART Non-Adherence: A Literature Review of Treatment Adherence by Gender from 2000 to 2011

“…Ten of the 44 studies (22.7%) reported significant differences in adherence between genders [8,16,31,37,46,65,70,73,78,84]. Of these, nine (90%) [8,16,31,46,65,70,73,78,84] [37] was conducted in Spain and used an adherence cutoff of 80%. It should be noted that the majority of articles did not specify whether there was a significant relationship between gender and adherence, as adherence by gender was not the main focus and/or because there was no significant relationship to report.…”

“…Additionally, women are more likely than men to be excluded and/or lost to follow-up, potentially resulting in a bias that omits the most vulnerable, and potentially least adherent, women [11,[34][35][36]. Despite this, there is still contradicting evidence including studies that find higher adherence in women [37] or no statistical difference between genders [12,[38][39][40][41][42].…”

Longitudinal Antiretroviral Adherence Among Adolescents Infected With Human Immunodeficiency Virus

“…7 In a comparison of tripledrug therapy (stavudine and lamivudine plus indinavir or nelfinavir), after a median follow-up of 9 months, 32% of the patients in the indinavir group and 50% of the patients in the nelfinavir group showed adequate adherence. 8 It is well documented that medication adherence to antiretroviral therapy is extremely difficult for patients with HIV. Overall, rates of adherence are poor for adolescents, adult women, and adult men.…”

HAART with didanosine once versus twice daily: adherence and efficacy

“…Similar methods of adherence assessment have been used in other studies. [18][19][20] For the purpose of this study the virological efficacy of treatment was defined as the presence of an HIV RNA level below detectable limits (<20 copies/ml). 20…”