A randomized comparative study to assess the efficacy of topical luliconazole versus topical clotrimazole in tinea corporis and tinea cruris

M, Lakshmi Prabha; Meenakshi, B; P, Nirmala Devi; J, Ezhil Ramya; C, Revathy Balan

doi:10.5455/njppp.2019.9.0415222052019

Cited by 1 publication

(12 citation statements)

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“…Dermatophytosis was reported in similar age groups (both mean and distribution) in these studies. 4,13,17 This study showed male predominance, the frequency of male patients was found almost double compare to the female on both study groups (65.2% vs 34.8% in Luliconazole treated group and 66.3% vs 33.7% in Clotrimazole treated group). Male predominance of suffering of both Tinea corporis and Tinea cruris reported in these studies.…”

Section: Discussionmentioning

confidence: 70%

“…Similar ratio was reported in these studies. 4,10 In contrast, Lakshmi CP et al and Khan I. observed almost equal frequencies of Tinea corporis and Tinea cruris in their sample. 13,18 Significant reduction of GAS observed in both Luliconazole and Clotrimazole treated group in this study.…”

Section: Discussionmentioning

confidence: 72%

“…Similar significant mean reduction difference at the end of first week and not significant mean difference at the end of treatment between the groups also reported in the study. 4 Significantly higher percentage of Luliconazole treated patients achieved mycological cure at the end of first week (68.6% vs 46.5%) and also at the end of treatment period (94.4% vs 81.4%) compared to the Clotrimazole treated group. Prabha et al observed similar mycological cure at the end of first week and at the end of treatment, those were also statistical significant (p=0.001 at the end of first week and p=0.01 at the end of treatment).…”

Section: Discussionmentioning

confidence: 88%

“…2,3 In India, the prevalence is ranging from 36.6% to 78.4%. 4 Dermatophytes are the most common organism which causes superficial infections, sometimes it's named as Tinea infection or dermatophytosis. It has three genera-Trichophyton spp., Microsporum spp., and Epidermophyton spp.…”

Section: Introductionmentioning

confidence: 99%

“…15 Based on the favorable efficacy and safety profile of Luliconazole is becoming popular rapidly in several countries of the world. 4,10,16 Materials and methods:…”

Section: Introductionmentioning

confidence: 99%

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Comparison of Efficacy between Topical Luliconazole and Topical Clotrimazole in the Treatment of Tinea Corporis and Tinea Cruris

Rashel ATM,

Chowdhury MAN,

Das HS

et al. 2023

JSWMC

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Background: The prevalence of Tinea Corporis and Tinea Cruris infections are increasing in Bangladesh due to its tropical climate, along with low socio-economic conditions. In treatment of these infections, Clotrimazole has been used for a long time. But Luliconazole is a newer drug which is offering more efficacy and tolerability with a short duration of treatment. Methods: An observational comparative study was directed to assess the efficacy of topical Luliconazole over Clotrimazole in the treatment of Tinea Corporis and Tinea Cruris among the 175 OPD patients of Department of Dermatology and Venereology, Sylhet MAG Osmani Medical College Hospital. The patient’s score was followed up by using 4-point scale of Global Assessment Score. Results: The mean age of Group A patients was 33.94±13.95 years and Group B was 32.64±13.15 years and male patients were predominant in both groups (65.2% and 66.3%). Tinea corporis was more prevalent in both groups (65.2% and 70.9%). The mean number of infection lesion was 2.35±1.12 and 2.30±1.13. The mean duration of infections was 3.33±5.98 months and 2.38±3.36 months in respective study groups. Papules found 61.4% and 51.4% among the patients respectively. Based on GAS, at the end of first week of treatment, significant difference in distributions found in case of erythema and papules. At the end of treatment, significant difference in distributions found in case of pruritus and scaling. At the 4 weeks after the end of treatment, significant difference in distributions found in case of pruritus, erythema and scaling (p<0.005). The mean GAS of Group A was 6.95±1.05 at baseline, which gradually decreased to 3.16±1.27, 1.02±1.01 and 0.42±1.32 in respective first, second and third visit. On the other side, in Group B, the mean GAS decreased from 7.21±1.27 to 3.87±1.28, 1.33±1.37 and 1.23±2.01 in respective baseline, first, second and third visit. Complete cure observed more patients in Group A (32.6%) compared to Group B (12.8%) after one weeks of treatment, whereas no response to treatment observed in more patients of Group B (55.8%) compared to Group A (28.1%). These changes in distribution were found significant (p=0.004). At the second visit, complete cure found in 89.9% patients in Group A and 77.9% patients in Group B. These distributions were reached the level of significance (p=0.031). At the last visit, only 2.2% of the completely cured patients of Group A and 16.3% of the completely cured patients of Group B developed relapse of the disease, which was also found significantly (p=0.001). Conclusion: Luliconazole found to be superior in terms of short duration of treatment course, less treatment failure and less relapse compared to that of the Clotrimazole.

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Section: Discussionmentioning

confidence: 70%

Section: Discussionmentioning

confidence: 72%

Section: Discussionmentioning

confidence: 88%

Section: Introductionmentioning

confidence: 99%

“…15 Based on the favorable efficacy and safety profile of Luliconazole is becoming popular rapidly in several countries of the world. 4,10,16 Materials and methods:…”

Section: Introductionmentioning

confidence: 99%

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