A randomized comparison between lercanidipine and amlodipine for efficacy and tolerability in patients with essential hypertension

Raparti, Girish Tulshidas; Choure, Balwant K.; Patil, Praveenkumar T.; Patne, Shailesh Shyamling

doi:10.18203/2319-2003.ijbcp20162233

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“…It ties emphatically to the lipid bi-layer of cell layers near the calcium channel receptor from where it is gradually delivered over resulting hours. This lethargic delivery from cell layers gives a 24-h term of pharmacological and restorative activity regardless of the medication's short plasma half-existence of roughly 2-5 hours [6].…”

Section: Introductionmentioning

confidence: 99%

Comparison Between Lercanidipine and Amlodipine for Efficacy and Tolerability in Patients with Hypertension

Abrar¹,

Rehman²,

Ali³

et al. 2021

PJMHS

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Introduction: Hypertension has been perceived as a worldwide health worry for non-industrial nations and is hardly depicted in a considerable lot of these nations. Objectives: The main objective of the study is to find the Comparison between lercanidipine and amlodipine for efficacy and tolerability in patients with hypertension. Material and methods: This cross sectional, comparative study was conducted in PIMS during January 2021 to June 2021. After permission from hospital ethical committee, total 120 patients meeting the inclusion and exclusion criteria will be enrolled in the study from Medical Emergency and admitted in PIMS. Detailed history, physical examination and necessary investigations will be done to meet the inclusion and exclusion criteria. Informed consent will be obtained. Results: The data was collected from 120 patients of both male and female. Table 01 shows the mean values of systolic and diastolic BP according to age and gender. The mean systolic and diastolic BP of all the study subjects were 124.2 ± 15.0 mmHg and 83.4 ± 9.5 mmHg, respectively. In men, the highest mean systolic BP and mean diastolic BP were among the eldest age group and preceding eldest age group. Conclusion: It is concluded that lercanidipine is associated with considerably lower incidence of vasodilation related side effects than amlodipine, especially pedal edema. Key words: Hypertension, Efficacy, Drugs, Therapy

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Section: Introductionmentioning

confidence: 99%