Venipuncture and intravenous cannulation are among the most common and widespread medical procedures performed on children today. Therefore, effective treatment of venous access pain can benefit from an integrated systems approach that enlists multiple players in the health care system. By using case studies that analyze this issue from the perspective of the nurse, the physician, the pharmacist, and the child life specialist, this article illustrates how multidisciplinary programs designed to manage needle pain have been developed successfully in several institutions. Common themes that arise from these case studies include the importance of a multidisciplinary evidence-based approach to advocate change; a system-wide protocol for the administration of local anesthetics; convenient access to topical local anesthetics; department and hospital-wide support for educational efforts, including training in nonpharmacologic techniques used by child life specialists; and ongoing quantification of the overall success of any program. Implementation of these strategies can result in significant improvements in the pediatric venous access experience. Pediatrics 2008;122:S161-S170 A TTITUDES ON PREVENTING procedural pain in children are changing as medical centers seek to comply with recent policy statements and clinical guidelines. The American Academy of Pediatrics and the American Pain Society recommend that efforts to soothe and minimize pediatric distress be considered even for minor procedures such as venipunctures. 1 A recent publication by the International Association for the Study of Pain cited humanitarian, ethical, and practical reasons for managing and preventing pediatric pain. 2 It is important to note that the management and prevention of pain in children is not limited to highly painful conditions and procedures but also includes the prevention of pain associated with venous access procedures whenever possible. 1 In this article we review the experiences of 5 children's hospitals in the United States that have well-developed peripheral venous access pain-management programs. The case studies, written by roundtable members integrally involved in the development of these programs, summarize the strategies that were used successfully in implementing systematic and multidisciplinary programs for the management of venous access pain in the individual hospitals.When the case studies are viewed in totality, a number of common strategies are found to be essential in moving the pediatric venous access pain-management programs from theory to practice: (1) assembling a multidisciplinary team to advocate change; (2) using an evidence-based approach to determine which interventions would best suit a particular institution; (3) using a system-wide protocol for the administration of local anesthetics in the hospital setting; (4) storing local anesthetics in patient care areas and using physician standing orders to facilitate access to these agents; (5) securing department and hospital-wide support of the programs ...