A Randomized Controlled Pilot Study of a Cognitive-Behavioral Therapy Approach for Painful Diabetic Peripheral Neuropathy

Otis, John D.; Sanderson, Kristen; Hardway, Christina; Pincus, Michael; Tun, Carlos G.; Soumekh, Sharona

doi:10.1016/j.jpain.2012.12.013

Cited by 50 publications

(53 citation statements)

References 28 publications

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“…There is insufficient evidence to make recommendations on psychological therapies for PDN from these studies. While the results from the pilot study carried out by Otis et al [35] appear encouraging, the high dropout rate limits the quality and validity of the findings. As highlighted previously patients have varying explanations for neuropathic pain, and varying levels of acceptance that psychological processes are relevant to their pain experiences [26].…”

Section: Discussionmentioning

confidence: 89%

“…The psychological coping interventions studied were CBT [35] and Mindfulness relaxation therapy [36]. There is insufficient evidence to make recommendations on psychological therapies for PDN from these studies.…”

Section: Discussionmentioning

confidence: 99%

“…There were two randomised controlled trials of psychological interventions, CBT and Mindfulness relaxation [35,36].…”

Section: Study Characteristics (Seementioning

confidence: 99%

“…Sample sizes ranged from 19-87, with only two studies reporting a sample size calculation [33,36]. The intervention arms were compared with treatment as A c c e p t e d M a n u s c r i p t usual [33][34][35] or a control arm of diabetes self-care education providing equivalent contact time with a health professional as the intervention arm [36].…”

Section: Study Characteristics (Seementioning

confidence: 99%

“…Otis et al [35] conducted Teixeira [36] studied the effect of mindfulness relaxation on PDN. Mindfulness relaxation aims to help people live with their pain, rather than fighting against it [37].…”

Section: Risk Of Bias and Quality Appraisalmentioning

confidence: 99%

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The role of physical activity and psychological coping strategies in the management of painful diabetic neuropathy – A systematic review of the literature

et al. 2015

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Section: Discussionmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 99%

“…There were two randomised controlled trials of psychological interventions, CBT and Mindfulness relaxation [35,36].…”

Section: Study Characteristics (Seementioning

confidence: 99%

Section: Study Characteristics (Seementioning

confidence: 99%

Section: Risk Of Bias and Quality Appraisalmentioning

confidence: 99%

See 3 more Smart Citations

The role of physical activity and psychological coping strategies in the management of painful diabetic neuropathy – A systematic review of the literature

et al. 2015

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Somatoform Disorders

DeGood¹,

Julien²,

DeGood³

2017

Cognitive Behavioral Psychopharmacology

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Activation of ephrinB–EphB receptor signalling in rat spinal cord contributes to maintenance of diabetic neuropathic pain

Deng

et al. 2016

European Journal of Pain

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Background: Diabetic neuropathic pain (DNP) is severe and intractable in clinic. The specific cellular and molecular mechanisms underlying DNP remain elusive and its treatment are limited. We investigated roles of EphB1 receptor in the development of DNP. Methods: Diabetic neuropathic pain was produced in male, adult, Sprague-Dawley rats by a single i.p. streptozotocin (STZ) or alloxan. Western blot analysis and immunohistochemistry were used to analyse expression of EphB1 receptor as well as the activation of the glial cells and the pro-inflammatory cytokines in the spinal cord. DNP manifested as mechanical allodynia, which was determined by measuring incidence of foot withdrawal in response to mechanical indentation of the hind paw by an electro von Frey filament. Results: Diabetic neuropathic pain and high blood glucose were exhibited simultaneously in around 70% of animals that received i.p. STZ or alloxan. Phosphorylation of EphB1, activation of the astrocytes and microglial cells, and level of tumour necrosis factor (TNF)-a and interleukin (IL)-1b in the spinal cord were significantly increased in rats with DNP. Spinal blocking EphB1 receptor activation in the late phase after STZ injection significantly suppressed the established mechanical allodynia as well as activation of the astrocytes and microglial cells and activity of TNF-a and IL-1b. However, spinal treatment of EphB1-Fc in the early phase after STZ injection did not prevent the induction of DNP. Conclusions: EphB1 receptor activation in the spinal cord is critical to the maintenance, but not induction of diabetic pain. EphB1 receptor may be a potential target for relieving the established diabetic pain. Significance: Activation of EphB1 receptor in the spinal cord is critical to maintaining the established diabetic neuropathic pain, but not to diabetic pain induction. Spinal blocking EphB1 receptor activation suppresses ongoing diabetic neuropathic pain.

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A Randomized Controlled Pilot Study of a Cognitive-Behavioral Therapy Approach for Painful Diabetic Peripheral Neuropathy

Cited by 50 publications

References 28 publications

The role of physical activity and psychological coping strategies in the management of painful diabetic neuropathy – A systematic review of the literature

The role of physical activity and psychological coping strategies in the management of painful diabetic neuropathy – A systematic review of the literature

Somatoform Disorders

Activation of ephrinB–EphB receptor signalling in rat spinal cord contributes to maintenance of diabetic neuropathic pain

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