A randomized controlled study to evaluate an experimental moisturizing mouthwash formulation in participants experiencing dry mouth symptoms

Abstract

The findings of a subjective questionnaire showed that an experimental moisturizing mouthwash provided greater relief than water only from dry mouth symptoms over 8 days.

Assessment of oral health problems and oral hygiene practices among palliative care patients using a new tool: A pilot study

“…In Brunei, most patients have been indicated with an oral mouthwash that has been designed to stimulate salivary production. This was in line with the study conducted by Jose et.al, which concluded that moisturising mouthwash provided greater relief than water only from dry mouth symptoms [28]. However, it was found that 41 out of 73 patients use mouthwash, just over half of the sample size (Table 2).…”

The association between oral dryness and use of dry-mouth interventions in Sjögren’s syndrome patients

“…Water is widely accessible at low costs. Drinking water can temporarily relieve the subjective sensation of dry mouth [ 30 , 31 ]. However, the effectiveness and longevity of this strategy are limited [ 27 ], because the viscosity of water does not change with increasing shear [ 32 ].…”

Effects of Xerostom® products on xerostomia in primary Sjögren’s syndrome: A randomized clinical trial

“…Although we extended the deadline to include more patients, new recruitment was difficult. Patients with such characteristics are not abundant and many of them are not well diagnosed or are under pharmacological treatments by their rheumatologist, as it was reported in other studies (Jose et al, ). In addition, many pSS patients have previously received many xerostomia treatments without success, and they do not want to start new trials.…”

“…For this reason, we found difficulties in comparing our results with previous studies. There are studies that did not find significant differences in improving xerostomia associated with pSS using other topical agents such as (Xialine) saliva substitute (Alpöz et al, ) and a mouthwash with cetylpyridinium chloride (Jose et al, ). Nonetheless, there are others that obtained positive results improving quality of life using a new natural formulation containing tea catechins (de Rossi et al, ).…”

“…There is no specific treatment for this disease and treatment is often focused on pharmacological interventions, but the evidence shows that the efficacy of sialogogues and other drug therapies in pSS is poor and side effects frequently hinder continuation of the therapy (Ramos‐Casals, Tzioufas, Stone, Sisó, & Bosch, ; Noaiseh, Baker, & Vivino, ; Papas et al, ). Treatment of xerostomia in pSS patients includes the administration of topical therapies, such as saliva substitutes and stimulants like sugar‐free chewing gum and lozenges (Alpöz et al, ; Furness, Worthington, Bryan, Birchenough, & McMillan, ; Hackett et al, ; Jose et al, ). pSS patients with residual salivary gland function could stimulate salivary flow with different systemic or local sialogogues such as pilocarpine (Papas et al, ; Fernández‐Martínez et al, ; Cifuentes, Barrio‐Díaz, & Vera‐Kellet, ; Watanabe et al, ) and cevimeline (Noaiseh et al, ).…”