A Randomized Controlled Trial Comparing Outcomes of Cataract Surgery in Nanophthalmos With and Without Prophylactic Sclerostomy

Rajendrababu, Sharmila; Babu, Naresh; Sinha, Sapna; Balakrishnan, Vijayakumar; Vardhan, Ashok; Puthuran, George Varghese; Ramulu, Pradeep Y.

doi:10.1016/j.ajo.2017.09.008

Cited by 44 publications

(37 citation statements)

References 27 publications

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“…Furthermore, intraocular surgeries in nanophthalmic eyes have significant risks and complications, both intraoperatively and postoperatively [ 3 , 25 , 42 , 43 ]. Proper preoperative planning and anatomic understanding can lead to good outcomes and improved quality of life in these patients [ 18 ], despite a nearly 40–60% rate of intraoperative complications [ 4 , 22 , 44 , 45 ].…”

Section: Nanophthalmos: Definition and Clinical Featuresmentioning

confidence: 99%

“…Small eyes may be associated with ophthalmic or systemic comorbidities. These eyes represent significant surgical challenges with a very high rate of intraoperative complications [ 4 ] and require a surgical approach that involves precision and care. Recognizing and correctly diagnosing the diverse presentations of this condition is of great importance for appropriate clinical and surgical management.…”

Section: Introductionmentioning

confidence: 99%

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Nanophthalmos: A Review of the Clinical Spectrum and Genetics

Carricondo

Andrade

Prasov

et al. 2018

Journal of Ophthalmology

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Nanophthalmos is a clinical spectrum of disorders with a phenotypically small but structurally normal eye. These disorders present significant clinical challenges to ophthalmologists due to a high rate of secondary angle-closure glaucoma, spontaneous choroidal effusions, and perioperative complications with cataract and retinal surgeries. Nanophthalmos may present as a sporadic or familial disorder, with autosomal-dominant or recessive inheritance. To date, five genes (i.e., MFRP, TMEM98, PRSS56, BEST1, and CRB1) and two loci have been implicated in familial forms of nanophthalmos. Here, we review the definition of nanophthalmos, the clinical and pathogenic features of the condition, and the genetics of this disorder.

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Section: Nanophthalmos: Definition and Clinical Featuresmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Nanophthalmos: A Review of the Clinical Spectrum and Genetics

Carricondo

Andrade

Prasov

et al. 2018

Journal of Ophthalmology

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“… 2 , 4 , 22 , 23 Uveal effusion is another well-known complication in nanophthalmic eyes, which can lead to secondary retinal detachment, vitreous hemorrhage, malignant glaucoma and loss of the eye. 4 , 24 , 25 , 26 This latter complication should be considered when choosing the type of anesthesia because retrobulbar and peribulbar anesthesia increase posterior pressure that may lead to vortex vein congestion. Instead, topical or general anesthesia is preferred.…”

Section: Discussionmentioning

confidence: 99%

Bilateral implantation of +56 and +58 diopter custom-made intraocular lenses in patient with extreme nanophthalmos

Scharf

Baur

Khoramnia

et al. 2020

American Journal of Ophthalmology Case Reports

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Purpose To present the case of a 60-year-old patient with severe nanophthalmic eyes, who underwent cataract surgery with a bilateral implantation of custom-made high-power intraocular lenses (IOLs). Observations The axial length was 14.94 and 15.05 mm of the right and the left eye, respectively. The preoperative corrected distance visual acuity (CDVA) was +0.46 logMAR (20/63) in the right eye and +0.58 logMAR (20/80) in the left eye with rigid contact lenses of +17.5 D bilaterally. The calculated IOL power for emmetropia with different formulas ranged from +55.28 to +70.09 D. The IOL power selection was based on the average value from four formulas (Haigis, Holladay 1, Holladay 2, SRK/T) with the target refraction of emmetropia. Custom-made +56.0 and + 58.0 D Aspira-aAY IOLs (HumanOptics AG, Erlangen, Germany) were implanted without any complications. The postoperative CDVA was +0.40 logMAR (20/50) and +0.60 logMAR (20/80). The manifest refraction spherical equivalents were +0.625 D and −0.375 D. Conclusions and importance Even in eyes with the axial length of only 15 mm, cataract surgery can be successfully performed after adequate preparation. High-power customized IOLs allow complete correction of hyperopia but caution is required with the results from different IOL power calculation formulas, which can be misleading.

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“…Wu et al [8] first included RCS thickness >1.70 mm into the diagnostic criteria of nanophthalmos in their 2004 report. Rajendrababu et al [29] referred to this standard and reported that the average RCS thickness in 60 nanophthalmic patients included in their study was 1.77∼2.20 mm. Kaewsangthong et al [30] measured the anterior scleral thickness in a nanophthalmic patient using an ultrasound biomicroscope.…”

Section: Increased Ickness and Structural Disorders Of The Scleramentioning

confidence: 99%

Nanophthalmos: An Update on the Biological Parameters and Fundus Abnormalities

Yang

Zhao

Liu

et al. 2021

Journal of Ophthalmology

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Nanophthalmos is a clinical phenotype of simple microphthalmos, in which the anterior and posterior segments of the eyeball do not develop into a normal size without other major ocular or systemic anomalies. Typical clinical manifestations of nanophthalmos include short axial length, thickened sclera, small cornea, shallow anterior chamber, and increased lens-to-eye volume ratio. Currently, there is a lack of recognized diagnostic criteria for nanophthalmos. With the development of eye examination technologies, such as biological measurement and imaging examination, visualization and quantification of the eyeball’s shape and structure in nanophthalmos can be realized. New clinical features have been reported, which are of great significance for diagnosing and treating nanophthalmos. This review introduces the related concepts of nanophthalmos and the new developments in its clinical characterization.

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A Randomized Controlled Trial Comparing Outcomes of Cataract Surgery in Nanophthalmos With and Without Prophylactic Sclerostomy

Cited by 44 publications

References 27 publications

Nanophthalmos: A Review of the Clinical Spectrum and Genetics

Nanophthalmos: A Review of the Clinical Spectrum and Genetics

Bilateral implantation of +56 and +58 diopter custom-made intraocular lenses in patient with extreme nanophthalmos

Nanophthalmos: An Update on the Biological Parameters and Fundus Abnormalities

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