A randomized controlled trial comparing a xyloglucan-based nasal spray with saline in adults with symptoms of rhinosinusitis

Abstract

A xyloglucan-based nasal spray provided greater relief of rhinosinusitis symptoms than a physiological saline spray and was well tolerated. Trial registration number (EUDRACT): 2014-000143-32.

The Effect of a Thixotropic Nasal Gel on Nasal Symptoms and Inflammatory Biomarkers in Seasonal Allergic Rhinitis

“…Overall, moderate and severe symptoms were experienced less frequently with treatment. These observations are in line with the results of trials investigating other gel preparations [4,5,7,9,10]. Furthermore, we found NP to significantly reduce nasal secretions, assessed by pre-and post-weight comparison of tissue-filled sachets.…”

“…All preparations studied have a high viscosity and are meant to entrap the pollen before they make contact with the nasal mucosa. Overall, the different products [4][5][6][7][8][9][10] were found to be effective in treating symptoms of AR, thus supporting the idea of a mechanical barrier against pollen. No study, however, examined the effects of these products in a controlled environment, nor their influence on biomarkers and cells of the allergic cascade.…”

“…These gels and ointments serve as a physical barrier and do not contain any pharmacologically active compounds. Some of these compositions have been investigated in clinical studies for efficacy in hay fever, for example, hypromellose [4][5][6], aliphatic long-chain hydrocarbons [7], ectoine [8], seawater gel [9], and xyloglucan [10]. All preparations studied have a high viscosity and are meant to entrap the pollen before they make contact with the nasal mucosa.…”

Rhinosectan® spray (containing xyloglucan) on the ciliary function of the nasal respiratory epithelium; results of an in vitro study

“…Thus, the effect of Rhinosectan ® on mucin secretion might indicate a positive role in the regulation of the secretion, which is crucial for essential nasal functions although further studies are needed on this issue and taking into account that oligomeric mucins alone do not constitute mucus, and other mucin and non-mucin components must be important contributors to mucus organization and hence airways defense [ 27 ]. This is also in agreement with the results of the recent randomized, double-blind clinical trial performed in patients with rhinosinusitis, in which the application of Rhinosectan ® significantly improved main symptoms and reduced the severity of rhinosinusitis in comparison with a physiological saline nasal spray [ 10 ].…”

“…Rhinosectan ® is specifically formulated for the control and reduction of symptoms related to rhinorrea and sinus congestion due to different etiologies, such as rhinitis (seasonal, perennial allergic, infectious or vasomotor rhinitis), sinus congestion due to cold or flu; and as symptomatic relief associated to the treatment of nasal polyps and acute sinusitis. Rhinosectan ® spray has been shown to significantly reduce rhinorrhea, itching, TNSS (total nasal symptom score) and the severity of rhinosinusitis, in comparison with physiological saline spray, in patients with rhinosinusitis, after nasal administration during 2 weeks [ 10 ].…”