A randomized controlled trial comparing continuous and as-required nitrous oxide use during screening colonoscopy

Ball, Alex; Din, Said; Donnelly, Mark; Riley, Stuart

doi:10.1097/meg.0000000000000281

Cited by 3 publications

(2 citation statements)

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“…Maleskar et al[ 31 ] found a high degree of patient satisfaction (median of 9.4) when they received nitrous oxide for analgesia. We emphasize that in both the studies by Ball et al[ 30 ] and by Maleskar et al[ 31 ], the procedure studied was colonoscopy, different from that of the present study.…”

Section: Discussioncontrasting

confidence: 63%

“…We have not found information regarding patient satisfaction with the type of analgesia received in previously published studies on nitrous oxide in transrectal ultrasound-guided prostate biopsy, which makes this result unprecedented. Ball et al[ 30 ] studied the degree of satisfaction of patients with continuous or intermittent use of nitrous oxide and obtained a high satisfaction rate, with means of 9.9 (± 0.4) in the continuous group and 9.7 (± 0, 9) in the intermittent group (p = 0.23). Maleskar et al[ 31 ] found a high degree of patient satisfaction (median of 9.4) when they received nitrous oxide for analgesia.…”

Section: Discussionmentioning

confidence: 99%

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A 50-50% mixture of nitrous oxide-oxygen in transrectal ultrasound-guided prostate biopsy: A randomized and prospective clinical trial

et al. 2018

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IntroductionTransrectal ultrasound-guided biopsy (TUSPB) is the standard method of diagnosis for prostate cancer, and although it is well tolerated by some patients, it presents a discomfort rate of 65 to 90%, which may be associated with pain. For convenience, it is agreed that a method of analgesia and sedation is necessary. For this purpose, this study aimed to evaluate the impact of inhalation of a 50–50% N2O-O2 gas mixture on pain intensity in these patients.Material and methodsRandomized, double-blinded clinical trial, conducted at Antônio Pedro University Hospital (Hospital Universitário Antônio Pedro), Niterói, RJ, Brazil, containing two groups of 42 patients: a control (C) group, which received 100% oxygen inhalation, and a nitrous oxide (NO) group, which received inhalation of the 50–50% N2O-O2 mixture, self-administered during TUSPB. The pain intensity and degree of satisfaction were evaluated through a visual analogue scale (VAS), as was the frequency of adverse events.ResultsEighty-four patients were included in the study, with 42 in each group. The mean pain intensity was lower in the NO group than in the C group [2.52 (0–10) vs 5.95 (0–10), p < 0.001], and the degree of satisfaction was higher in the NO group than in the C group (8.14 vs. 4.69, p < 0.001). The adverse effects were somnolence, dizziness, nausea, vomiting, discomfort and euphoria without differences between the groups.ConclusionThe 50–50% N2O-O2 mixture was effective in reducing pain intensity and increasing the degree of satisfaction in TUSPB, with tolerable side effects.

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Section: Discussioncontrasting

confidence: 63%

Section: Discussionmentioning

confidence: 99%

A 50-50% mixture of nitrous oxide-oxygen in transrectal ultrasound-guided prostate biopsy: A randomized and prospective clinical trial

et al. 2018

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General Anaesthetics and Therapeutic Gases

Jha¹,

Flockton²

2016

Side Effects of Drugs Annual

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British Society of Gastroenterology guidelines on sedation in gastrointestinal endoscopy

Sidhu,

Turnbull,

Haboubi

et al. 2023

Gut

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Over 2.5 million gastrointestinal endoscopic procedures are carried out in the United Kingdom (UK) every year. Procedures are carried out with local anaesthetic r with sedation. Sedation is commonly used for gastrointestinal endoscopy, but the type and amount of sedation administered is influenced by the complexity and nature of the procedure and patient factors. The elective and emergency nature of endoscopy procedures and local resources also have a significant impact on the delivery of sedation. In the UK, the vast majority of sedated procedures are carried out using benzodiazepines, with or without opiates, whereas deeper sedation using propofol or general anaesthetic requires the involvement of an anaesthetic team. Patients undergoing gastrointestinal endoscopy need to have good understanding of the options for sedation, including the option for no sedation and alternatives, balancing the intended aims of the procedure and reducing the risk of complications. These guidelines were commissioned by the British Society of Gastroenterology (BSG) Endoscopy Committee with input from major stakeholders, to provide a detailed update, incorporating recent advances in sedation for gastrointestinal endoscopy.This guideline covers aspects from pre-assessment of the elective ‘well’ patient to patients with significant comorbidity requiring emergency procedures. Types of sedation are discussed, procedure and room requirements and the recovery period, providing guidance to enhance safety and minimise complications. These guidelines are intended to inform practising clinicians and all staff involved in the delivery of gastrointestinal endoscopy with an expectation that this guideline will be revised in 5-years’ time.

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A randomized controlled trial comparing continuous and as-required nitrous oxide use during screening colonoscopy

Abstract: Among patients attending for screening colonoscopy, comfort ratings were similar in those using Entonox continuously and as required, but light headedness was more common with continuous use (NCT identifier: 01865721).

Cited by 3 publications

References 22 publications

A 50-50% mixture of nitrous oxide-oxygen in transrectal ultrasound-guided prostate biopsy: A randomized and prospective clinical trial

A 50-50% mixture of nitrous oxide-oxygen in transrectal ultrasound-guided prostate biopsy: A randomized and prospective clinical trial

General Anaesthetics and Therapeutic Gases

British Society of Gastroenterology guidelines on sedation in gastrointestinal endoscopy

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