A Randomized Controlled Trial of Cognitive Remediation Among Inpatients With Persistent Mental Illness

Lindenmayer, Jean-Pierre; McGurk, Susan R.; Mueser, Kim T.; Khan, Anzalee; Wance, Deborah; Hoffman, Lisa; Wolfe, Rosemarie; Xie, Haiyi

doi:10.1176/ps.2008.59.3.241

Cited by 130 publications

(59 citation statements)

References 26 publications

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“…COGPACK is a computerized, commercially available CR program developed for persons with severe mental illness, with demonstrated efficacy in schizophrenia. 26,28,29 The curriculum of COGPACK exercises used in the current study is similar to that used in past controlled trials. 22,26,30 The curriculum consists of a standardized set of computerized exercises that provides practice of the broad range of cognitive functions and overlaps with cognitive domains assessed by the MCCB-MATRICS.…”

Section: Neurocognitive Interventionmentioning

confidence: 99%

“…Additional features of MRIGE that contribute to its feasibility for use in schizophrenia is that it provides individualized practice that is adjusted to patient performance levels and allows a high degree of control and autonomy to users, features that have contributed to the feasibility of computerized CR in schizophrenia. 26 The aim of the present study was to compare the effects of a 12-week CR program (CR alone), having demonstrated efficacy on neurocognition in the patient population included in the present study, with CR combined with MRIGE, a novel training program of emotion perception (CR + MRIGE), on measures of emotion perception, social functioning, and neurocogniton. Our hypothesis was that the combined CR + MRIGE intervention would result in greater improvements in social cognition and measures of social functioning compared with CR alone.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Improving Social Cognition in Schizophrenia: A Pilot Intervention Combining Computerized Social Cognition Training With Cognitive Remediation

Lindenmayer

McGurk

Khan

et al. 2012

Schizophrenia Bulletin

123

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Section: Neurocognitive Interventionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Improving Social Cognition in Schizophrenia: A Pilot Intervention Combining Computerized Social Cognition Training With Cognitive Remediation

Lindenmayer

McGurk

Khan

et al. 2012

Schizophrenia Bulletin

123

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“…Results indicated that patients in the CRT group demonstrated significantly greater improvements over 3 months than the control group in overall cognitive functioning, psychomotor speed, and verbal learning, and worked more weeks than the control group over the 12-month follow-up period. 59 These findings suggest that this program may be beneficial for patients with significant functional and symptomatic impairments.…”

Section: Monthsmentioning

confidence: 93%

“…For example, Lindenmayer et al evaluated the feasibility and efficacy of a CRT program for improving cognitive and work functioning for intermediate-to longstay psychiatric inpatients. 59 In this study, symptoms were assessed with the Positive and Negative Syndrome Scale at submit your manuscript | www.dovepress.com baseline, midtreatment, posttreatment, and at 6-month and 12-month follow-ups. Results indicated that patients in the CRT group demonstrated significantly greater improvements over 3 months than the control group in overall cognitive functioning, psychomotor speed, and verbal learning, and worked more weeks than the control group over the 12-month follow-up period.…”

Section: Monthsmentioning

confidence: 99%

Support management in schizophrenia: a systematic review of current literature

Pompili¹,

Montebovi²,

Forte³

et al. 2012

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Background: Schizophrenia is generally considered a chronic disorder characterized by psychotic symptoms and relatively stable neurocognitive and interpersonal deficits. Antipsychotic medication has proven beneficial in reducing psychotic symptoms, but is often not enough to treat cognitive or functional impairments. Residual cognitive impairments are barriers to a patient's full recovery from schizophrenia. Rehabilitation is an alternative and important approach which may be useful, and encompasses a variety of treatments including social skills training and psychoeducational and cognitive behavioral treatments. Objective: To investigate the efficacy of psychosocial treatments in schizophrenia, evaluating its effects in the short and long term, comparing psychosocial treatments with pharmacotherapy, and assessing the effects of treatment and the main indications for use in patients with schizophrenia. Methods: A careful MEDLINE ® , Excerpta Medica, PsycLIT ® , PsycINFO ® , and IndexMedicus search was performed to identify all papers and book chapters in English for the period 1970-2012. Results:Findings from the studies included in this qualitative analysis suggest that social skills therapy, cognitive behavioral therapy, family intervention therapy, cognitive remediation therapy, and other nonpharmacological therapeutic strategies may be beneficial for patients with significant functional and symptomatic impairments. Conclusion: Schizophrenic patients treated with nonpharmacological techniques have more rapid remission and relapse less frequently than patients treated only pharmacologically.

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“…A number of studies in the reviews we have summarized typically involved young-adult or middle-aged white males (27); however, skills training programs have been adapted successfully for Latino clients (36,48), including outpatient services for older people with psychotic disorders of long duration. Some studies have included substantial numbers of participants with different ethnic and racial backgrounds in their study samples (49), including a number of studies with participants who were predominantly African American (50,51). Examples of other cross-cultural studies include an RCT of illness self-management conducted with hospitalized individuals with schizophrenia in Japan (33) and an RCT of successful skill-building interventions conducted in a Chinese psychiatric hospital (52).…”

Section: Level Of Evidencementioning

confidence: 99%

Skill Building: Assessing the Evidence

Lyman¹,

Kurtz²,

Farkas³

et al. 2014

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Objective: Skill building for adults involves multiple approaches to address the complex problems related to serious mental illness. Individuals with schizophrenia are often the research focus. The authors outline key skillbuilding approaches and describe their evidence base. Methods: Authors searched meta-analyses, research reviews, and individual studies from 1995 through March 2013. Databases surveyed were PubMed, PsycINFO, Applied Social Sciences Index and Abstracts, Sociological Abstracts, Social Services Abstracts, Published International Literature on Traumatic Stress, ERIC, and CINAHL. Authors chose from three levels of evidence (high, moderate, and low) on the basis of benchmarks for the number of studies and quality of their methodology. They also described the evidence of service effectiveness. Results: Over 100 randomized controlled trials and numerous quasi-experimental studies support rating the level of evidence as high. Outcomes indicate strong effectiveness for social skills training, social cognitive training, and cognitive remediation, especially if these interventions are delivered through integrated approaches, such as Integrated Psychological Therapy. Results are somewhat mixed for life skills training (when studied alone) and cognitive-behavioral approaches. The complexities of schizophrenia and other serious mental illnesses call for individually tailored, multimodal skill-building approaches in combination with other treatments. Conclusions: Skill building should be a foundation for rehabilitation services covered by comprehensive benefit plans that attend to the need for service packages with multiple components delivered in various combinations. Further research should demonstrate more conclusively the long-term effectiveness of skill building in real-life situations, alone and in various treatment combinations. Studies of diverse subpopulations are also needed. (Psychiatric Services 65:727-738, 2014; doi: 10.1176/appi.ps.201300251) D eveloping or regaining basic skills needed to function adaptively in real-world situations is essential for individuals who are struggling with serious mental illness, substance use disorders, or co-occurring mental and substance use disorders. The neurodevelopmental nature of certain severe mental illnesses (1)-in which multiple and complex skill deficits emerge early in development, persist through adulthood in the absence of targeted treatment, and affect virtually every aspect of life functioning-has led to a vast array of approaches to skill building. These approaches are typically applied in various combinations.The inherent complexity of skill building adds a high degree of challenge to assessing levels of evidence and effectiveness for such a diverse array of treatment modalities and methods. In this review, we examined four key components of skill building: social skills training (including life skills training), social cognitive training, cognitive remediation, and cognitivebehavioral therapies that target skills for coping with psychotic pr...

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A Randomized Controlled Trial of Cognitive Remediation Among Inpatients With Persistent Mental Illness

Cited by 130 publications

References 26 publications

Improving Social Cognition in Schizophrenia: A Pilot Intervention Combining Computerized Social Cognition Training With Cognitive Remediation

Improving Social Cognition in Schizophrenia: A Pilot Intervention Combining Computerized Social Cognition Training With Cognitive Remediation

Support management in schizophrenia: a systematic review of current literature

Skill Building: Assessing the Evidence

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