A randomized controlled trial of the effect of dietary soy and flaxseed muffins on quality of life and hot flashes during menopause

Lewis, Jacqueline; Nickell, Leslie; Thompson, Lilian U.; Szalai, John Paul; Kiss, Alex; Hilditch, John R.

doi:10.1097/01.gme.0000191882.59799.67

Cited by 88 publications

(62 citation statements)

References 40 publications

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“…In this study, there were no significant effects on hot flash frequency or severity in either the soy or flax group (Lewis et al, 2006). Another randomized doubleblind controlled trial performed in 72 breast cancer patients who consumed 70 mg isoflavones/day or placebo for 12 weeks showed no significant effects of the isoflavones (MacGregor et al, 2005), consistent with other trials performed in breast cancer patients (Quella et al, 2000;Van Patten et al, 2002).…”

Section: Discussionsupporting

confidence: 85%

“…These four controlled trials differ from a study that evaluated symptoms in 87 early postmenopausal women who consumed muffins containing either flaxseed, soy flour (containing 42 mg isoflavones), or wheat flour daily for 16 weeks (Lewis et al, 2006). In this study, there were no significant effects on hot flash frequency or severity in either the soy or flax group (Lewis et al, 2006).…”

Section: Discussionmentioning

confidence: 70%

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Soy consumption for reduction of menopausal symptoms

Kurzer

2008

Inflammopharmacol

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Section: Discussionsupporting

confidence: 85%

Section: Discussionmentioning

confidence: 70%

Soy consumption for reduction of menopausal symptoms

Kurzer

2008

Inflammopharmacol

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“…This represents a serious public health challenge regarding the search for new alternatives to prevent and postpone diseases that can interfere with the quality of life of this population (1,2). There is an increasing number of women with contraindications for hormonal therapy or with a preference for more natural treatments because they fear the side effects or repercussions of clinical trials within this field (3,4).…”

Section: Introductionmentioning

confidence: 99%

Consumption of a Flaxseed-Rich Food Is Not More Effective Than a Placebo in Alleviating the Climacteric Symptoms of Postmenopausal Women

Simbalista

Sauerbronn

Aldrighi

et al. 2010

The Journal of Nutrition

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Our objective in this work was to test the effects of daily intake of bread produced with partially defatted ground flaxseed on the climacteric symptoms and endometrial thickness of postmenopausal women. A double-blind, placebo-controlled, randomized clinical trial was performed with 38 women who had been postmenopausal for 1-10 y and consumed 2 slices of bread containing 25 g of flaxseed (46 mg lignans) or wheat bran (<1 mg lignans; control) every day for 12 consecutive weeks. The outcome variables were the daily number of hot flashes, the Kupperman Menopausal Index (KMI), and endometrial thickness. The plasma lipid profile (total cholesterol and HDL, LDL, and VLDL cholesterol fractions and triglycerides) and the hormones estradiol, follicle-stimulating hormone, thyroid-stimulating hormone, and free thyroxine also were measured. Food intake was evaluated by means of 2 24-h recalls, before and after the treatment. Twenty patients in the study group and 18 in the control group completed the study. The general characteristics did not differ between the 2 groups at the start of the study. Both had significant, but similar, reductions in hot flashes and KMI after 3 mo of treatment. Moreover, endometrial thickness was not affected in either group. Our findings clearly show that although flaxseed is safe, its consumption at this level (46 mg lignans/d) is no more effective than placebo for reducing hot flashes and KMI.

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“…Well designed trials should be conducted in order to demonstrate the efficacy and the safety of these herbal medicines. 23 Asian women have different health risk benefit of HT. 20 It is important to adopt a management option of menopause which are culturally acceptable.…”

Section: The Future Of Menopause Management In Asian Womenmentioning

confidence: 99%

Menopause and the Asian Woman

Sohail¹

2014

Journal of SAFOMS

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Menopause is an event that typically occurs in women in midlife. For some women, the accompanying symptoms can significantly disrupt their daily activities and sense of well being. It has long been known that menopause is much easier for Asian women than for westerners. A systematic review of articles on Asian women is done, the objective of which is to find out evidence on Asian women experience and perception of menopause.

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A randomized controlled trial of the effect of dietary soy and flaxseed muffins on quality of life and hot flashes during menopause

Abstract: Neither dietary flaxseed nor soy flour significantly affected menopause-specific quality of life or hot flash symptoms in this study.

Cited by 88 publications

References 40 publications

Soy consumption for reduction of menopausal symptoms

Soy consumption for reduction of menopausal symptoms

Consumption of a Flaxseed-Rich Food Is Not More Effective Than a Placebo in Alleviating the Climacteric Symptoms of Postmenopausal Women

Menopause and the Asian Woman

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