A randomized controlled trial of vaginal misoprostol tablet and intracervical dinoprostone gel in labor induction of women with prolonged pregnancies

Mandal, Ardhendu; Chattopadhyay, Shibram; Choudhuri, Snehamoy; Malo, Samaresh; Patra, Kajal Kumar; Ganguly, Sharmistha; Maiti, Debmalya

doi:10.18203/2320-1770.ijrcog20160367

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“…4 With regard to prostaglandin administration, a prostaglandin E2 (dinoprostone, PGE2) vaginal suppository is the preferred method for cervical ripening and induction of labor, and it is widely used in clinical practice. 5 PGE2 is the only prostaglandin that is approved by the Food and Drug Administration of the United States for cervical ripening in pregnant women near or at term with a medical or obstetric indication. 6 The controlled-release vaginal PGE2 not only relaxes cervical smooth muscle and promotes cervical dilatation, but also stimulates the synthesis and release of endogenous PGE2.…”

Section: Introductionmentioning

confidence: 99%

Prediction of the induction to delivery time interval in vaginal dinoprostone-induced labor: a retrospective study in a Chinese tertiary maternity hospital

et al. 2019

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Objective This study aimed to investigate the potential factors that affect the induction to delivery time interval in women undergoing induction of labor with a controlled-release dinoprostone vaginal insert. Methods Pregnant women who presented for delivery at Hubei Maternal and Child Health Hospital from January 2016 to August 2016 were recruited. Finally, 1265 women who underwent labor induction with a vaginal dinoprostone (PGE2) insert were analyzed. Univariate and multivariate linear regression analyses were used to estimate the relevant risks for delivery time. Results Among the1265 subjects, the mean delivery time was 18.92 ± 12.50 hours. Univariate and multivariate analyses showed that fetal weight, an obstetric complication (premature rupture of the membranes), and the delivery history were significantly associated with the induction to delivery time. Biparietal diameter was related to the vaginal delivery time in univariate analysis, but there was no significant difference after adjustment in multivariate analysis. Conclusions Vaginal dinoprostone is an effective method for successful induction of labor. Gestational age, parity, and fetal weight are major factors that predict the induction to delivery time interval.

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Section: Introductionmentioning

confidence: 99%