Telemedicine has applications in all stages of the diagnosis, treatment, and follow-up of patients with sleep-disordered breathing. Diagnostic applications include telemonitored polysomnography, communication of test results and therapeutic options, and remote continuous positive airway pressure titration. Online compliance monitoring results in similar and in some cases improved compliance when compared with traditional face-to-face evaluations. The impact of telemedicine on compliance depends on the preexisting organization of standard care in the routine setting. Combining theory-driven behavioral approaches with telemedicine technology could hold the answer to increasing real-world adherence rates. Targeted troubleshooting and support based on individual patient data, web-, and/or app-based teaching, and combinations via a smartphone app or coaching website is feasible. Telemedicine is likely cost-effective but requires better evidence.