1999
DOI: 10.1086/314948
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A Randomized, Controlled Trial of Indinavir, Zidovudine, and Lamivudine in Adults with Advanced Human Immunodeficiency Virus Type 1 Infection and Prior Antiretroviral Therapy

Abstract: A randomized, double-blind, multicenter study of indinavir, zidovudine, and lamivudine was conducted in 320 adults with human immunodeficiency virus type 1 (HIV-1) infection, Show more

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Cited by 91 publications
(34 citation statements)
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“…Third, pre-treatment viremia <50,000 copies/ ml, CD4+ T-cel1counts> 150/JlIand lack of previous exposure to antiretroviral drugs at the time of starting dual NRTI regimens were all conditions independently associated with virologic response, as documented by results ofthe logistic regression model of multivariate statistical analysis and in keeping with other authors (5)(6)(8)(9)(23)(24)(25).…”
Section: / Adjusted For Sex Duration Of Infection Cdc Status Cd8+supporting
confidence: 84%
“…Third, pre-treatment viremia <50,000 copies/ ml, CD4+ T-cel1counts> 150/JlIand lack of previous exposure to antiretroviral drugs at the time of starting dual NRTI regimens were all conditions independently associated with virologic response, as documented by results ofthe logistic regression model of multivariate statistical analysis and in keeping with other authors (5)(6)(8)(9)(23)(24)(25).…”
Section: / Adjusted For Sex Duration Of Infection Cdc Status Cd8+supporting
confidence: 84%
“…As with any phenotypic assay, it is important to appreciate that the lower limit of detection of mixtures may vary (from 10 to 40%) depending on the mutant virus. Treatment failure (i.e., the loss of suppression of virus replication) now affects a significant number of infected individuals receiving highly active ARV therapy (8,18,24,30; for a review, see reference 32). The emergence of multidrug-resistant virus represents a significant obstacle in maintaining longterm suppression of virus replication in both treatment-naive and -experienced patients.…”
Section: Figmentioning
confidence: 99%
“…28 6. Significant CD4 T-cell increases following PI-containing regimen compared to non-PI-containing regimens, even in the face of inferior antiviral outcomes [29][30][31] (see Figure 1). …”
Section: 23mentioning
confidence: 99%