A randomized controlled trial of 400-μg sublingual misoprostol versus manual vacuum aspiration for the treatment of incomplete abortion in two Egyptian hospitals

Abstract

The high efficacy, safety, and acceptability of 400-μg sublingual misoprostol indicate that it is analogous to surgery as a first-line treatment for incomplete abortion. Misoprostol might improve post-abortion care when resources are limited and surgical treatment is unavailable.

Interest of manual vacuum aspiration in the management of incomplete abortion at the district hospital of n’djamena south, chad

“…MVA was conducted with efficiency (100%). Our result is like those of numerous authors in the literature 6,[12][13] . The efficiency of MVA showed the advantage this method in the treatment of incomplete abortions.…”

Oral misoprostol as first‐line care for incomplete abortion in Burkina Faso

“…A more recent study comparing 400μg sublingually with manual vacuum aspiration (MVA) in 2 Egyptian hospitals provided further evidence that the sublingual dose works well: 98.3% of participants experienced complete uterine evacuation with the regimen [8]. Data from this study and others show that misoprostol is analogous to MVA as first-line treatment for incomplete abortion [8].…”

“…Indeed, although a recent publication [12] on scaling-up postabortion care made curiously little mention of medical management-despite the copious availability of evidence and the inclusion of misoprostol on the WHO Model List of Essential Medicines [9] for this indication-the authors did advocate for continued momentum to expand access to postabortion care. There is ample clinical evidence of high safety, efficacy, and satisfaction rates with this method [2][3][4][5][6][7][8] and a favorable policy climate, given the inclusion of misoprostol on the Model List of Essential Medicines and recommendations by FIGO [13]. The time has now come to scale-up a Values are given as number (percentage).…”

“…A more recent study comparing 400μg sublingually with manual vacuum aspiration (MVA) in 2 Egyptian hospitals provided further evidence that the sublingual dose works well: 98.3% of participants experienced complete uterine evacuation with the regimen [8]. Data from this study and others show that misoprostol is analogous to MVA as first-line treatment for incomplete abortion [8]. In 2009, WHO added misoprostol to its Model List of Essential Medicines for the treatment of spontaneous and incomplete abortion, remarking that the "evidence showed that misoprostol is as effective as surgery and in some settings may be safer as well as cheaper" [9].…”

Dilatation and curettage versus manual vacuum aspiration for first trimester clandestine abortions

“…According to some authors, MVA is safer and has almost the same outcome as medical termination of pregnancy with misoprostol. 15 The mean hospital stay in our study was longer in the D&C group with a statistically significant difference. This has also been reported by other authors.…”