A Randomized Controlled Trial of Omega 3 Fatty Acids in Rosacea Patients with Dry Eye Symptoms

Bhargava, Rahul; Chandra, Mini; Bansal, Utsav; Singh, Divya; Ranjan, Somesh; Sharma, Shalini

doi:10.3109/02713683.2015.1122810

Cited by 71 publications

(81 citation statements)

References 20 publications

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“…60 In fact, various animal and human studies have shown that omega 3 fatty acids (from which resolvins and protectins are derived) improved symptoms, signs, and inflammation associated with dry eye. [63][64][65][66][67] This effect is likely mediated through the biosynthetic process of omega fatty acids to resolvins and protectins. For example, neuroprotectin D1 (a product of docosahexaenoic acid (DHA)) was found to be as effective as DHA itself in improving corneal sensitivity and tear production and decreasing neutrophil infiltration after experimental nerve injury.…”

Section: Peripheral Sensitizationmentioning

confidence: 99%

Neuropathic ocular pain: an important yet underevaluated feature of dry eye

Galor

Levitt

Felix

et al. 2014

Eye

185

187

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Dry eye has gained recognition as a public health problem given its prevalence, morbidity, and cost implications. Dry eye can have a variety of symptoms including blurred vision, irritation, and ocular pain. Within dry eyeassociated ocular pain, some patients report transient pain whereas others complain of chronic pain. In this review, we will summarize the evidence that chronicity is more likely to occur in patients with dysfunction in their ocular sensory apparatus (ie, neuropathic ocular pain). Clinical evidence of dysfunction includes the presence of spontaneous dysesthesias, allodynia, hyperalgesia, and corneal nerve morphologic and functional abnormalities. Both peripheral and central sensitizations likely play a role in generating the noted clinical characteristics. We will further discuss how evaluating for neuropathic ocular pain may affect the treatment of dry eye-associated chronic pain.

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Section: Peripheral Sensitizationmentioning

confidence: 99%

Neuropathic ocular pain: an important yet underevaluated feature of dry eye

Galor

Levitt

Felix

et al. 2014

Eye

185

187

View full text Add to dashboard Cite

show abstract

“…and a change in mean of 3.86 sec. Bhargava R. et al, 24 demonstrated a change in mean of 3.3 sec after 3 months treatment (325EPA+125DHA), Kangari et al demonstrated a change in mean of 1.7 sec after only a month's treatment. Although supplementation duration and its quantity varies in these studies, but there is a definite agreement about the beneficial effect of Omega 3 on this parameter.…”

Section: Discussionmentioning

confidence: 99%

Twelve Weeks Treatment Outcome of Omega-3 Fatty Acid in Computer Vision Syndrome Dry Eye: An Open Label, Randomized, Controlled Pilot Study

Thakur¹,

Agarwal²,

Jain³

et al. 2016

jemds

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“…Chinnery, et al found that Omega-3 supplementation imparts neuroprotective effects in the cornea sub-basal plexus which correlate with improvement in tear osmolarity [25]. In another study, rosacea patients showed improvement in symptoms, TBUT, Schirmer score and Meibomian gland score (MGS) with six months of Omega 3 supplementation [26]. An of ice-based study involving 1,419 patients in Spain found multiple bene its in dry eye sufferers utilizing a supplement that contained a combination of Omega-3 fatty acids, vitamins, minerals, and antioxidants [27].…”

mentioning

confidence: 90%