A randomized controlled trial of exercise on augmenting the effects of cognitive remediation in persons with severe mental illness

McGurk, Susan R.; Otto, Michael W.; Fulford, Daniel; Cutler, Zachary; Mulcahy, Leonard P.; Talluri, Sai Snigdha; Qiu, Wei Qiao; Gan, Qini; Tran, Ivy; Turner, Laura; DeTore, Nicole R.; Zawacki, Stacey; Khare, Chitra; Pillai, Anilkumar; Mueser, Kim T.

doi:10.1016/j.jpsychires.2021.04.033

Cited by 11 publications

(5 citation statements)

References 56 publications

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“…This lack of improvement also occurred in the study by McGurk et al [42], although in this case, the variable studied was cognitive functioning. They proposed a programme combining moderate aerobic physical activity with cognitive recovery exercises.…”

Section: Discussionsupporting

confidence: 59%

“…Nevertheless, a number of conclusions could be drawn. The barriers most taken into account were those related to personal (except for the side effects of medication) [20,30,33,36,37,42] and programme factors (organizational barriers and environmental constraints) [9,42,43]. This point is important as it is one of the easiest to control and directly intervenes on personal factors such as the appearance of symptoms or negative emotions that may result from these barriers, as well as on the level of motivation.…”

Section: Discussionmentioning

confidence: 99%

“…However, based on the particularities of each proposal, it has been possible to draw a series of conclusions. Three facilitators clearly stand out in the results (outdoor activities, inclusion of the social component and the possibility of adapting the activities) [30,36,42,43], as they allow moments of exchange of ideas and knowledge and, therefore, the support of the participants and the possibility of improvement through the knowledge acquired. However, there are also other possibilities related to the intensity of the activities [38,39] and to more personal factors such as the development of autonomy [9,34] or social support [37,39,40].…”

Section: Discussionmentioning

confidence: 99%

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Benefits, Facilitators and Barrier Reductions in Physical Activity Programmes for People with Severe Mental Disorder: A Systematic Review

et al. 2023

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The current high prevalence of people with Severe Mental Disorder and the high impact the latter has on their quality of life is one of the main problems in terms of health, as it affects both physical and mental health. One of the lines of action to intervene in these factors is the practice of physical activity, as this usually has a low level of participation due to different barriers. However, there are several facilitators that improve adherence to these practices. The main objectives of this work were (1) to conduct a systematic review of the scientific literature on the possible benefits obtained by people with SMD from their participation in physical activity programmes; (2) to identify the characteristics of physical activity programmes and determine the barriers to their implementation that have been considered and (3) the facilitators incorporated. To meet these objectives, the SCOPUS, Web of Science, PubMed, Dialnet and Elsevier online databases were consulted and, following the PRISMA statement, 17 articles were finally selected. Their analysis has revealed various physical, psychological and social benefits, as well as the barriers that appear in the intervention programmes, mostly related to personal factors and the programme itself, and those factors that facilitate their adherence or development, the most common being the carrying out of the activities outdoors, the inclusion of social components and the possibility of adapting the activities. In this way, the results obtained have made it possible to highlight the characteristics that should be taken into account when planning this type of intervention.

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Section: Discussionsupporting

confidence: 59%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Benefits, Facilitators and Barrier Reductions in Physical Activity Programmes for People with Severe Mental Disorder: A Systematic Review

et al. 2023

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“…However, results on the combined effects of CR + exercise occasionally inconsistent. McGurk et al (2021) evaluated if the increase of brain derived neurotropic factor (BDNF), following exercise may mediate improved cognitive functioning, but results did not show that exercise augments CR, possibly because the cognitive remediation program resulted in strong gains in cognitive functioning ( McGurk et al, 2021 ).…”

Section: Treatment Of Cognitionmentioning

confidence: 99%

Cognitive dysfunction in schizophrenia: An expert group paper on the current state of the art

Harvey

Bosia

Cavallaro

et al. 2022

Schizophrenia Research: Cognition

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“…Another pilot study found that lifestyle intervention including exercise program showed improvement in overall functioning assessed by The Longitudinal Interval Follow-Up Evaluation-Range of Impaired Functioning Tool, but no differences in mood symptoms between groups ( 28 ). A randomized controlled trial found that 30-h aerobic exercise intervention did not augment cognition compared to the control group ( 29 ). A recent randomized trial, examining effects of N-acetylcysteine for BD, found that patients with BD who engaged more physical activity may reduce more scores on the Bipolar Depression Rating Scale.…”

Section: Introductionmentioning

confidence: 99%

Effect of online aerobic exercise training in patients with bipolar depression: Protocol of a randomized clinical trial

et al. 2022

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IntroductionBipolar disorder (BD) is a common and debilitating mental illness that affects about 400 million people worldwide, decreasing their functionality and quality of life. Medication and psychotherapy are recommended for treatment of BD, while some evidence indicates that exercise could improve the clinical outcome of BD. This study aims to investigate whether exercise intervention could reduce the mood symptoms and inflammation level of BD.MethodsThis is a longitudinal, interventional, randomized, and single-blind trial. We plan to recruit 94 patients diagnosed with BD in depression episode. Patients will be randomly assigned to treatment as usual + aerobic exercise group (intervention group) and treatment as usual (TAU) only group, at a ratio of 1:1. The intervention group will undergo 40-min aerobic exercise training twice a week for eight weeks. The primary outcome of this study is the mean change of Hamilton Depression Rating Scale 17 (HAMD 17) scores from baseline to week 8. The Young Manic Rating Scale (YMRS), Self-Rating Depression Scale (SDS), and Interleukin-6 (IL-6), Tumor necrosis factor-α (TNF-α) and C-reactive protein (CRP) levels will also be measured. The measurements will be performed at baseline, immediately after intervention and two months after intervention.DiscussionAerobic exercise training + treatment is expected to bring more benefits to BD patients than TAU only. This trial might provide stronger evidence of physical exercise efficacy for BD treatment.Clinical trial registrationThis study was approved by the Chinese Clinical Trial Registry (Registration Code: ChiCTR2200057159). Registered on 1 March 2022.

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A randomized controlled trial of exercise on augmenting the effects of cognitive remediation in persons with severe mental illness

Cited by 11 publications

References 56 publications

Benefits, Facilitators and Barrier Reductions in Physical Activity Programmes for People with Severe Mental Disorder: A Systematic Review

Benefits, Facilitators and Barrier Reductions in Physical Activity Programmes for People with Severe Mental Disorder: A Systematic Review

Cognitive dysfunction in schizophrenia: An expert group paper on the current state of the art

Effect of online aerobic exercise training in patients with bipolar depression: Protocol of a randomized clinical trial

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