ABSTRACT. Objective:In the present study, we examined whether we could replicate previous findings that use of protective behavioral strategies (PBSs) mediates the associations between distal antecedents and alcohol-related outcomes in an independent sample. Further, we examined a more comprehensive model to determine which constructs uniquely (i.e., controlling for other distal antecedents) relate to PBS use and alcohol-related outcomes. Method: Participants were recruited from a psychology department participant pool at a large, southwestern university in the United States (N = 628). The majority of participants identified themselves as being either Hispanic (n = 334, 53.18%) or White, non-Hispanic (n = 212, 33.78%), were female (n = 386, 61.5%), and reported a mean age of 20.30 (SD = 3.80) years. Results: Across five replication attempts in separate models, we found significant indirect associations of age at first use, self-regulation, impulsivity-like traits, depressive symptoms, and conscientiousness on alcohol-related outcomes (i.e., use and problems) via PBS use. However, only the indirect associations of a second-order latent factor of self-regulation (based on premeditation, perseverance, self-regulation, and conscientiousness) and age at first use on alcohol-related outcomes via PBS use remained significant in the comprehensive model. Conclusions: Taken together, the replication attempts were largely successful in that nearly all associations were replicated in an independent sample of college students. However, in a comprehensive model with all distal antecedents simultaneously included, most of the direct and indirect associations failed to be supported. (J. Stud. Alcohol Drugs, 77, 958-967, 2016)