A Randomized Controlled Trial of Conbercept Pretreatment before Vitrectomy in Proliferative Diabetic Retinopathy

Abstract

Purpose. To determine the efficacy and safety of preoperative intravitreal conbercept (IVC) injection before vitrectomy for proliferative diabetic retinopathy (PDR). Methods. 107 eyes of 88 patients that underwent pars plana vitrectomy (PPV) for active PDR were enrolled. All patients were assigned randomly to either preoperative IVC group or control group. Follow-up examinations were performed for three months after surgery. The primary bioactivity measures were severity of intraoperative bleeding, incidence of early and late recurrent VH, vitreous clear-up time, and best-corrected visual acuity (BCVA) levels. The secondary safety measures included intraocular pressure, endophthalmitis, rubeosis, tractional retinal detachment, and systemic adverse events. Results. The incidence and severity of intraoperative bleeding were significantly lower in IVC group than in the control group. The average vitreous clear-up time of early recurrent VH was significantly shorter in IVC group compared with that in control group. There was no significant difference in vitreous clear-up time of late recurrent VH between the two groups. Patients that received pretreatment of conbercept had much better BCVA at 3 days, 1 week, and 1 month after surgery than control group. Moreover, both patients with improved BCVA were greater in IVC group than in control group at each follow-up. Conclusions. Conbercept pretreatment could be an effective adjunct to vitrectomy in accelerating postoperative vitreous clear-up and acquiring stable visual acuity restoration for PDR.

Observation of optic disc neovascularization using OCT angiography in proliferative diabetic retinopathy after intravitreal conbercept injections

“…Relatively few studies have been performed on the intravitreal injection of conbercept for the treatment of neovascularization in PDR. Some studies have focused on preoperative conbercept pretreatments and found that it could be an effective adjunct to vitrectomy by reducing the chances of intraoperative bleeding, accelerating postoperative vitreous clear-up and helping stabilize visual acuity restoration for PDR 23 , 24 .…”

Difference in the Vitreal Protein Profiles of Patients with Proliferative Diabetic Retinopathy with and without Intravitreal Conbercept Injection

“…Similar to aflibercept, conbercept (Kanghong Biotechnologies), the newest VEGF Trap, is a recombinant fusion protein composed of the second Ig domain of VEGFR1 and the third and fourth Ig domains of VEGFR2 fused to the constant region of human IgG1, and it acts as a receptor with affinity to all informs of VEGF and PlGF [ 5 – 7 ]. Preoperative conbercept treatment also allows patients with PDR to undergo surgery more quickly, with less risk of intra- or postoperative bleeding, and to have better postoperative BCVA [ 12 , 13 ], but the mechanisms are not fully understood.…”

“…Similarly, intravitreal conbercept (IVC) is better than posterior subtenon triamcinolone acetonide for diabetic macular edema in the proliferative stage of PDR [ 11 ]. Preoperative conbercept treatments also allow patients with PDR to undergo surgery more quickly, with less risk of intra- or postoperative bleeding, and result in a better postoperative BCVA [ 12 , 13 ]. Moreover, conbercept and ranibizumab are effective in the treatment of diabetic macular edema, with similar clinical efficacy, but conbercept has a longer treatment interval and fewer IVC injections are needed [ 14 ].…”

The effect of adjunctive intravitreal conbercept at the end of diabetic vitrectomy for the prevention of post-vitrectomy hemorrhage in patients with severe proliferative diabetic retinopathy: a prospective, randomized pilot study

“…Other studies, have reported the opposite effects [12][13][14]. Conbercept (Chengdu Kanghong Biotech Co., Ltd., Sichuan, China) is a type of anti-VEGF agent, which has been widely used for curing patients with agerelated macular degeneration (AMD) and macular edema and has been reported to be an effective adjunct when injected before vitrectomy for PDR [15]. The aim of the present study was to investigate the role of conbercept in the prevention of postoperative vitreous hemorrhage when injected at the end of vitrectomy for severe PDR.…”