A Randomized Controlled Trial of Magnesium Sulfate, in Addition to Usual Care, for Rate Control in Atrial Fibrillation

Davey, Michael; Teubner, David John Osmond

doi:10.1016/j.annemergmed.2004.09.013

Cited by 53 publications

(37 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Their meta-analysis pooled four trials (303 patients) and eight trials (476 patients), respectively, for acute rate control (<100 beats ⁄ min) and rhythm control and included the trials by Davey and Teubner 5 and Walker et al 11 The therapies against which magnesium was compared in these pooled trials were varied. Magnesium or placebo was given in addition to standard therapy.…”

Section: Discussionmentioning

confidence: 99%

“…More commonly, previous investigators have compared magnesium in addition to standard therapy against standard therapy alone. Standard therapies have included a variety of antiarrhythmic agents including digoxin, [3][4][5]11 verapamil, 6,7 diltiazem, 8 and amiodarone. 12 These studies have all reported apparent benefits of magnesium in the treatment of supraventricular tachyarrhythmias, including AF.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Magnesium Sulfate versus Placebo for Paroxysmal Atrial Fibrillation: A Randomized Clinical Trial

Chu¹,

Evans²,

Emerson³

et al. 2009

Academic Emergency Medicine

View full text Add to dashboard Cite

Objectives: The objective was to investigate the efficacy of magnesium sulfate (MgSO 4 ) in decreasing the ventricular rate in emergency department (ED) patients presenting with new-onset, rapid atrial fibrillation (AF).Methods: A double-blinded, placebo-controlled randomized clinical trial was conducted in an adult university hospital. Patients aged ‡18 years with AF onset of less than 48 hours and a sustained ventricular rate of >100 beats ⁄ min were randomized to either intravenous (IV) MgSO 4 10 mmol or normal saline (NSal). Rhythm and instantaneous heart rate as measured by the monitor were recorded at baseline and every 15 minutes for 2 hours after starting the trial drug. Heart rate and rhythm were compared at 2 hours. A multilevel modeling analysis was performed to adjust for differences in baseline heart rate and any additional treatment and to examine changes in heart rate over time.Results: Twenty-four patients were randomized to MgSO 4 and 24 to NSal. Baseline heart rate was lower in the MgSO 4 group (mean ± standard deviation [±SD] = 125 ± 24 vs. 140 ± 21 beats ⁄ min]. One and 3 patients in the MgSO 4 and NSal groups, respectively, were given another antiarrhythmic or were electrically cardioverted within 2 hours after starting the trial drug. Heart rate (mean ± SD) at 2 hours in both MgSO 4 (116 ± 30 beats ⁄ min) and NSal groups (114 ± 31 beats ⁄ min) decreased below their respective baseline levels. However, the rate of heart rate decrease across time did not differ between groups (p = 0.124). The proportion of patients who converted to sinus rhythm 2 hours post-trial drug did not differ (MgSO 4 8.7% vs. NSal 25.0%, p = 0.25).Conclusions: This study was unable to demonstrate a difference between IV MgSO 4 10 mmol and saline placebo for reducing heart rate or conversion to sinus rhythm at 2 hours posttreatment in ED patients with AF of less than 48 hours duration.ACADEMIC EMERGENCY MEDICINE 2009; 16:295-300 ª

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Magnesium Sulfate versus Placebo for Paroxysmal Atrial Fibrillation: A Randomized Clinical Trial

Chu¹,

Evans²,

Emerson³

et al. 2009

Academic Emergency Medicine

View full text Add to dashboard Cite

show abstract

“…13 In 199 patients receiving rate control for rapid AF (again mostly with digoxin), those randomized to intravenous supplemental magnesium were more likely to reach a rate of <100 beats per minute at 2 hours (relative risk, 1.89; 95% confidence interval, 1.38-2.59). 19 Although these results are encouraging, magnesium has not been widely adopted as a rate control strategy, as more effective agents are available for acute ventricular rate control, such as β-blockers, verapamil, and diltiazem.…”

Section: See Article By Rajagopalan Et Almentioning

confidence: 99%

Magnesium for Atrial Fibrillation, Myth or Magic?

Kotecha

2016

Circ: Arrhythmia and Electrophysiology

View full text Add to dashboard Cite

“…325 Most studies showed no conversion benefit for magnesium (LOE 1), 327,328 although 1 meta-analysis showed conversion benefit (LOE 1). 329 Most studies showed a benefit for magnesium in rate control (LOE 1), 295,329,330 although 1 study was neutral for magnesium for rate control (LOE 1). 328 Quinidine has been shown to have greater conversion than sotalol in 2 studies (LOE 1), 331,332 although this was with greater toxicity.…”

Section: Consensus On Sciencementioning

confidence: 99%